Nouvelle déclaration d'incident
No de la demande: 2018-4382
Numéro de référence du titulaire d'homologation: 2018-US-12522
Nom du titulaire (nom légal complet, aucune abbréviation): Merck Animal Health (Intervet Canada Corp)
Adresse: 16750 Transcanada Highway
Ville: Kirkland
État: Quebec
Pays: Canada
Code postal /Zip: H9H 4M7
Incident chez un animal domestique
Pays: UNITED STATES
État: UNKNOWN
ARLA No d'homologation ARLA No de la demande d'homologation EPA No d'homologation. 773-95
Nom du produit: Activyl Tick Plus Toy Dog
Liquide
Oui
Unités: mL
Site: Animal / Usage sur un animal domestique
Inconnu
Professionnel de la santé
Dog / Chien
Chihuahua
1
Femme
9.0
4.0
lbs
Cutanée
<=15 min / <=15 min
>2 hrs <=8 hrs / > 2 h < = 8 h
Système
>8 hrs <=24 hrs / > 8 h < = 24 h
Oui
Oui
1
Day(s) / Jour(s)
Mort
Treatment / Traitement
(p.ex. description des symptômes tels que la fréquence et la gravité
Suspected Adverse Reaction: On 03 Jul 2018 a veterinary assistant reported that her own 4-pound Chihuahua developed neurologic signs after Activyl Tick Plus for Dogs and Puppies (over 4 lb and up to 11 lb) was applied for the first time on 02 Jul 2018. The veterinarian faxed records provided additional information. The dog had a history of an enlarged heart and of trauma earlier in the month (family member sat on dog - owner wasn't home to witness event). The dog had been receiving an oral liquid furosemide for breathing problems (pre-existing fluid in chest). The owner applied the product around 8 pm. Approximately 4 hours later the owner woke up and heard the dog wheezing and thought the dog was acting weird (verbatim). The owner administered a dose of the oral furosemide. Early in the morning on 03 Jul 2018 the owner woke up to find the dog seizuring on the bathroom floor. See 19. for continuation
Mort
(continuation)-The owner bathed the dog with Dawn, took it to the vet clinic and administered atropine intra-muscularly (per the veterinarian's instructions to reverse the permethrin toxicity). The dog was hypothermic at 96.2F. The vet treated the dog with toxiban, Lasix, dexamethasone and intravenous fluids. Later that morning the temperature was normal at 100.6. A chemistry panel revealed a hypoalbuminemia of 2.4 g/dL (2.5 - 4.4), an elevated BUN of 31 mg/dL (7-25) and a hyperphosphatemia of 8.7 mg/dL (2.9-6.6). A complete blood count revealed a leukopenia of 24.63 X10E9/l (6 - 17), a monocytosis of 1.58 X10E9/l (0.2 - 1.5, a neutrophilia of 21.76 X10E9/l (3 - 12) and a thrombocytopenia of 65 X10E9/l (165- 500). The dog had improved but continued to have muscle twitching and horizontal nystagmus. The dog did not have nystagmus at rest but did when moved. The vet did not feel it was positional. The dog was responding and seems more alert. On 05 Jul 2018 the owner reported that the dog had died with continued neurologic signs (began seizuring again) on 03 Jul 2018. Additional information on 13 Jul 2018 was received from the owner that the dog had not had a necropsy and had been cremated. No additional information expected.