Nouvelle déclaration d'incident
No de la demande: 2016-5171
Numéro de référence du titulaire d'homologation: 160087245
Nom du titulaire (nom légal complet, aucune abbréviation): Wellmark International
Adresse: 100 Stone Road West, Suite 111
Ville: Guelph
État: Ontario
Pays: Canada
Code postal /Zip: N1G5L3
Incident chez un animal domestique
Pays: UNITED STATES
État: NORTH CAROLINA
ARLA No d'homologation ARLA No de la demande d'homologation EPA No d'homologation. 89459-4
Nom du produit: Adams for Cats Flea and Tick Spot On for 5 Lbs and Over
Liquide
Oui
Unités: mL
Site: Animal / Usage sur un animal domestique
Propriétaire de l'animal
Cat / Chat
Domestic Longhair
1
Homme
2.0
7.0
lbs
Cutanée
Unknown / Inconnu
>3 days <=1 wk / >3 jours <=1 sem
Système
Persisted until death
Non
Non
Mort
Treatment / Traitement
(p.ex. description des symptômes tels que la fréquence et la gravité
On June 10, 2016 the cat developed weight loss, anorexia, adipsia, and lethargy. On June 13, 2016 the cat developed tachypnea, seizure, and died shortly after. On June 16, 2016 the owner contacted the Animal Product Safety Service (APSS). The APSS veterinarian stated etofenprox is a non-ester pyrethroid and the mechanism of action (MOA) is similar to pyrethroids. A necropsy was not available.
Mort
The APSS veterinarian stated that the substance was considered to have a doubtful likelihood of causing the clinical situation.
Propriétaire de l'animal
Cat / Chat
Domestic Shorthair
1
Femme
5.0
9.0
lbs
Cutanée
>1 wk <=1 mo / > 1 sem < = 1 mois
>3 days <=1 wk / >3 jours <=1 sem
Système
Persisted until death
Non
Non
Mort
Treatment / Traitement
(p.ex. description des symptômes tels que la fréquence et la gravité
On June 13, 2016 the cat started hiding, became lethargic, and developed anorexia. On June 16, 2016 the owner noticed the cat had developed dyspnea, the owner then bathed the cat (Dawn; tons of fleas), and shortly after the cat developed white mucous membranes. A short time later, the owner noted the cat died in his arms. The owner then contacted the Animal Product Safety Service. The APSS veterinarian stated etofenprox is a non-ester pyrethroid and the mechanism of action (MOA) is similar to pyrethroids. The APSS veterinarian recommended a necropsy and provided information (how to store body and have veterinarian call us in the morning).
Mort
On June 17, 2016 the veterinary staff called the APSS to inquire why they were involved or why the owner cannot submit the body himself. On June 19 and 20, 2016 the APSS technician attempted to contact the veterinary clinic to discuss the necropsy submission. On June 20, 2016 the veterinary staff returned the APSS technician's call and stated the body was in the freezer, the forms had been faxed to the clinic, she had already spoken with someone at the University of Illinois (U of I), and the package pickup was scheduled for that day or the next. On June 22 and 23, 2016 the APSS staff discussed private cremation with the owner, which the owner declined due to cost. On June 30, 2016 the veterinary staff contacted the APSS as they had received the necropsy results and were wondering how to proceed as they did not want to be involved since the patient was never seen at the facility. The APSS assistant stated that no APSS veterinarians were available to transfer so the clinic requested a call back the following day. On July 1, 2016 the APSS technician called the veterinary staff and provided the fax number so that the results could be faxed over. On July 7, 2016 the APSS received the final necropsy results. The necropsy revealed a pulmonary arterial thromboembolism and a mild multifocal bronchiolar smooth muscle hyperplasia, the heart a rare focal arteriosclerosis, the liver diffuse, severe, centrilobular to massive hepatocellular degeneration. The necropsy also stated the extent of autolysis is remarkable and may be obscuring clinically significant lesions. The necropsy further stated hepatocellular degeneration is suggestive of hypoxemia or toxicity. On July 7, 2016 the APSS veterinarian called the owner to discuss the necropsy results. The APSS veterinarian stated the most significant findings were a pulmonary thrombus and hepatocelluar necrosis with no definitive causes for these findings. The APSS veterinarian finally stated hypoxia from the flea anemia may have contributed to the hepatic damage, although this could not be confirmed due to autolysis.