Nouvelle déclaration d'incident
No de la demande: 2015-4348
Numéro de référence du titulaire d'homologation: 150052418
Nom du titulaire (nom légal complet, aucune abbréviation): Wellmark International
Adresse: 100 Stone Road West, Suite 111
Ville: Guelph
État: Ontario
Pays: Canada
Code postal /Zip: N1G5L3
Incident chez un animal domestique
Pays: UNITED STATES
État: NEW JERSEY
ARLA No d'homologation ARLA No de la demande d'homologation EPA No d'homologation. 2724-829-89459
Nom du produit: Adams Pentagon Flea And Tick Spot On For Extra Large Dogs 61-150 Lbs
Liquide
Oui
Unités: oz (fl) / oz (liquide)
Site: Animal / Usage sur un animal domestique
Propriétaire de l'animal
Dog / Chien
Old English Sheepdog
1
Femme
5.0
95.0
lbs
Cutanée
Unknown / Inconnu
>24 hrs <=3 days / >24 h <=3 jours
Système
Persisted until death
Oui
Oui
1
Day(s) / Jour(s)
Mort
Treatment / Traitement
(p.ex. description des symptômes tels que la fréquence et la gravité
On April 8, 2015 the dog developed lameness and hyperthermia with a temperature of 103.5 degrees Fahrenheit (deg F), so the owner took the dog to the veterinarian where a carprofen injection was given and prescribed and laser therapy was performed. On April 13, 2015 the dog started retching, having diarrhea, developed anorexia, and adipsia, and lethargy. On April 16, 2015 the owner took the dog to the veterinarian where the lameness had ended, the carprofen was discontinued, the dog's hyperthermia continued with a temperature of 103.6 deg F. The dog was given maropitant and fluid therapy (subcutaneous (SQ)). On April 17, 2015 the dog went back to the veterinarian where a urinalysis was performed (owner let the attending veterinarian know that the dog had been incontinent for a month), the dog was diagnosed with neutropenia and dohle bodies, and cephalexin (1000 milligrams every 12 hours (mg q 12) was prescribed. On April 21, 2015 the dog returned to the veterinarian where the lethargy worsened and the hyperthermia had become severe; with the dog's temperature at 107.2 deg F and the dog developed tachycardia with a heart rate of 150 beats per minute (bpm). The dog was also depressed, had a stiff gait, and was hesitant to move. The dog was hospitalized for supportive care, given an antibiotic, a tick profile performed (negative 4 DX and Tick PCR), and referred to a specialist. On April 22, 2015 the veterinary specialist performed bone marrow aspiration (most consistent with "toxic" changes, dysplasia shown), radiographs (thoracic and adominal), a joint tap, and an ultrasound. The dog was prescribed doxycycline (200 mg q 12) and metoclopramide (10 mg q 12) and the dog was discharged from the specialist's hospital with lymphadenopathy (left popliteal lymph node (LN) is enlarged) and the neutropenia becoming severe. On April 23, 2014 the dog's hyperthermia ended and the owner contacted the Animal Product Safety Service (APSS). The APSS veterinarian stated dermal hypersensitivity and paresthesia may be seen. The APSS assistant recommended the owner have the attending veterinarian call for information. On April 24, 2015 the attending veterinarian called the APSS to discuss the case. The attending veterinarian stated that the diagnosis was still open and the APSS veterinarian stated that these signs are not expected from the spot on, that chemotherapy medications and topical creams should be considered. The attending veterinarian stated that she had already asked the owner about medications, creams, etc.
Mort
The APSS veterinarian stated that the substance was considered to have a doubtful likelihood of causing the clinical situation. On April 29, 2015 an APSS technician called the owner to follow-up on the case. On May 2, 2015 the owner called the APSS and stated the dog had died on April 28, 2015, no necropsy had been done as the dog had been cremated. The owner stated that there had been no final diagnosis; it was still an unknown toxic insult to the dog's bone marrow.