Nouvelle déclaration d'incident
No de la demande: 2011-0888
Numéro de référence du titulaire d'homologation: 110010152
Nom du titulaire (nom légal complet, aucune abbréviation): Farnam Companies, Inc.
Adresse: 301 W. Osborn Road
Ville: Phoenix
État: Arizona
Pays: USA
Code postal /Zip: 85013
Incident chez un animal domestique
Pays: UNITED STATES
État: CALIFORNIA
ARLA No d'homologation ARLA No de la demande d'homologation EPA No d'homologation. 270-255
Nom du produit: Apache Fly Bait
Appât
Non
Inconnu
Professionnel de la santé
Dog / Chien
Labrador Retriever
1
Homme
3.0
65.0
lbs
Orale
>8 hrs <= 24 hrs / >8 h <= 24 h
>30 min <=2 hrs / >30 min <=2 h
Système
Persisted until death
Oui
Oui
Inconnu
Mort
Accidental ingestion/Ingestion accident.
(p.ex. description des symptômes tels que la fréquence et la gravité
On January 24, 2011 the owner took the dog to the regular veterinarian, who noticed the dog had tremors, seizures, and was unconscious. Shortly after, the regular veterinarian gave the dog Atropine, fluid therapy, and Diazepam. That day, the dog was transferred to an emergency veterinary clinic. Shortly after arriving at the emergency clinic, the emergency veterinarian contacted the Animal Product Safety Service (APSS) to obtain help. The APSS veterinarian stated that it was necessary to competitively inhibit acetylcholinesterase (AchE) by binding to its esteric site. The APSS veterinarian further stated that without AchE, Ach accumulates and causes excessive synaptic neurotransmitter activity. The APSS veterinarian went on to state that because carbamates bind with acetylcholine on a reversible basis, the inhibition of acetylcholinesterase is temporary, and thus carbamates have a shorter duration of action than organophosphate insecticides. The APSS veterinarian further stated that any exposure to the product can cause clinical signs and that the muscarinic signs include the SLUD signs (excessive salivation, lacrimation, urination, and defecation) as well as miosis, dyspnea, vomiting, and bradycardia. The APSS veterinarian stated that dyspnea is the result of increased bronchial secretions, bronchoconstriction, and decreased contraction of the respiratory muscles. Finally, the APSS veterinarian stated that common signs are tremors, seizures, hypersalivation, vomiting, and ataxia, and that one might also see diarrhea, hyperthermia, lethargy, miosis, and death. Later that day, the dog began vomiting and developed diarrhea. The APSS veterinarian recommended giving the dog Methocarbamol, Diazepam, Barbiturate, and fluid therapy. The APSS veterinarian also recommended managing the seizures and tremors, monitoring for respiratory sounds, heart rate and rhythm, and for signs of aspiration, managing vomiting, supporting respiratory function, monitoring the dog at a veterinary facility, and obtaining additional information about the owner and the exposure to the product. The APSS veterinarian also stated that the dog had received a large amount of atropine and that further administration was not recommended.
Mort
The APSS veterinarian stated that the substance was considered to have a high likelihood of causing the clinical situation. On January 24, 2011, the APSS veterinarian called the emergency veterinary clinic to update the case and found out that the emergency veterinarian performed a gastric lavage. On January 26, 2011 an APSS assistant called the emergency veterinary clinic to update the case and found out the dog died on the morning of January 25, 2011.