New incident report
Incident Report Number: 2024-1589
Registrant Reference Number: 2024-US-003024
Registrant Name (Full Legal Name no abbreviations): Evergreen Animal Health, LLC
Address: 22655 Centennial Road
City: Gretna
Prov / State: Nebraska
Country: USA
Postal Code: 68028
Domestic Animal
Country: UNITED STATES
Prov / State: FLORIDA
PMRA Registration No. PMRA Submission No. EPA Registration No. 92334-1-93176
Product Name: Wags Advance for Dogs 4-10 lbs 1 dose Spot-on
Liquid
Yes
Unknown
Site: Animal / Usage sur un animal domestique
Animal's Owner
Dog / Chien
Chihuahua
1
Female
9
5
lbs
Skin
Unknown / Inconnu
>30 min <=2 hrs / >30 min <=2 h
System
Persisted until death
No
No
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On 07-Feb-2024, a 9 year old, approximately 5 pound, neutered, female, Chihuahua dog, in unknown condition, with a concomitant medical condition of an unknown heart condition, was administered 1 tube of Wags Advance for Dogs 4-10 lbs 1 dose (Imidacloprid, Permethrin, Pyriproxyfen) via the topical route by the animal owner. Approximately 1 hour after administration, the dog developed anorexia. On 08-Feb-2024, the dog developed tachypnea. Bathing the dog with dish soap to remove the product was recommended. If following bathing, signs were not improving, then veterinary evaluation was recommended. On 12-Feb-2024, the dog died. No further information was provided.
Death
Assessment: Imidacloprid, permethrin, and pyriproxyfen have a wide margin of safety in dogs. Systemic absorption does not occur with dermal application of the product and signs such as increased respiratory rate and death would not be expected nor in the toxicological profile of the active ingredients. There is not enough information in the case to determine if the outcome is related to the product. Given the dog's signalment and history of an unspecified heart condition, congestive heart failure is a more likely cause of death. Other causes should be considered including infectious disease, thromboembolism, unknown trauma and toxic exposure though without a necropsy the cause of death cannot be confirmed. The information contained in this report is based on self-reported statements provided to the registrant during telephone interview(s). These self-reported descriptions of an incident have not been independently verified to be factually correct or complete descriptions of the incident. For that reason, information contained in this report does not and cannot form the basis for a determination of whether the reported clinical effects are causally related to exposure to the product identified in the telephone interviews.