New incident report
Incident Report Number: 2024-0076
Registrant Reference Number: M-501339-01-1
Registrant Name (Full Legal Name no abbreviations): BAYER CROPSCIENCE INC.
Address: 160 QUARRY PARK BOULEVARD SE SUITE 130
City: CALGARY
Prov / State: AB
Country: CANADA
Postal Code: T2C 3G3
Scientific Study
PMRA Registration No. 19204 PMRA Submission No. EPA Registration No.
Product Name: PHENMEDIPHAM TECHNICAL HERBICIDE
Unknown
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Title Acute toxicity of BCS-AU61245 (m-toluidine) to the waterflea Daphnia magna in a static laboratory test system - Final report
Date 30-OCT-14
No
Increased health or environmental risk
The minor metabolite of phenmedipham, BCS-AU61245 (m-toluidine), was tested on Daphnia magna for 48 hours in a static exposure system to nominal concentrations of 20, 40, 80, 160, 320 and 640 Aug pure metabolite / L (corresponding to mean-measured concentrations of 17.5, 34.2, 68.4, 142, 295 and 582 Aug pure metabolite / L) in comparison to a control. The study was performed according to OECD test guideline 202 and OCSPP test guideline 850.1010. Test conditions met all guideline validity criteria. The 48-hour EC50=100 Aug pure metabolite/L (95% C.L. = 83 to 119 Aug pure metabolite/L) was based on immobilization of the daphnids. These values were lower than the previously reported daphnia 48-hour endpoints used in the risk assessment, which were determined as EC50=2033 Aug phenmedipham/L, and EC50=1880 Aug desmedipham/L.
No
Phenmedipham is moderately toxic to freshwater aquatic animals on an acute exposure basis. The aquatic invertebrate study with a phenmedipham metabolite met reportability criteria for Canada due to lower endpoints as compared to the acute daphnia study (Daphnia magna). The lower endpoints do not affect the risk assessment for phenmedipham as the level of concern was low for adverse effects to freshwater invertebrates.