New incident report
Incident Report Number: 2023-0374
Registrant Reference Number: M-826549-01-1
Registrant Name (Full Legal Name no abbreviations): Bayer CropScience Inc.
Address: Suite 200, 160 Quarry Park Boulevard SE
City: CALGARY
Prov / State: AB
Country: Canada
Postal Code: T2C 3G3
Scientific Study
PMRA Registration No. 31450 PMRA Submission No. EPA Registration No.
Product Name: FLUPYRADIFURONE TC
Unknown
Unknown
Title Feeding Inhibition test with Cloeon dipterum exposed to Flupyradifurone (non-GLP study)
Date 14-DEC-22
No
Increased health or environmental risk
Larvae of the mayfly, Cloeon dipterum, were exposed to six waterborne concentrations of flupyradifurone (and control) in three different aquatic exposure scenarios under semi-static conditions. In each exposure scenario, there were twenty replicates per control and treatment group with one larvae per replicate. Results indicated that under exposure scenarios A (144 hours of flupyradifurone exposure), B (120 hours of flupyradifurone exposure), and C (104 hours of flupyradifurone exposure), mortality and immobility of larvae was increased relative to controls at concentrations 22.5 g a.i./L. Under all three exposure scenarios, partial mortality was observed at 22.5 and 33.8 g a.i./L flupyradifurone, and near complete or complete mortality was observed at concentrations of flupyradifurone 50.6 g a.i./L.
No
The study was designed to provide toxicity data for development and calibration of an ecological effects model and not with the purpose of deriving regulatory endpoints. The study design included fasting and non-fasting phases. Additionally, the study period included total exposure times ranging from 104 to 144 hours, which is greater than standard acute toxicity test designs with aquatic invertebrates, which generally measure mortality over 48 hours.