New incident report
Incident Report Number: 2022-1011
Registrant Reference Number: ProPharma Group case #: 2022SCPU00038311
Registrant Name (Full Legal Name no abbreviations): Syngenta Canada Inc.
Address: 140 Research Lane, Research Park
City: Guelph
Prov / State: Ontario
Country: Canada
Postal Code: N1G4Z3
Human
Country: UNITED STATES
Prov / State: UNKNOWN
Unknown
PMRA Registration No. PMRA Submission No. EPA Registration No. Unknown
Product Name: DIQUAT TECHNICAL
Liquid
Unknown
Unknown
Other
Sex: Male
Age: >6 <=12 yrs / > 6 < = 12 ans
System
Persisted until death
Yes
Yes
2
Day(s) / Jour(s)
Non-occupational
Poisoning from ingestion of the pesticide
Unknown
Oral
Unknown / Inconnu
>2 hrs <=8 hrs / > 2 h < = 8 h
2022SCPU00038311 - Acute diquat ingestion: probably responsible Scenario/Substances: An 8 y/o male drank a mouthful from a soda bottle, thinking it was soda. He experienced nausea, 5 vomiting episodes,and throat irritation between the time of ingestion and the time of presentation to the ED (within 3 hours). The ingested substance was initially unidentified. Physical Exam: BP 158/86, HR 130, O2 Sat, 100% on RA, T 37C.Laboratory/Diagnostic Findings: 1st ED visit: BUN 18, Cr 0.49, WBC18.2. 2nd ED visit: Na 135/K 3.6/Cl 108/CO2 13/BUN 33/Cr 3.22, AST 1,109,ALT 944, C-reactive protein 44.6 mg/L, WBC 28.9/Hgb 16.2/, Hct 48.8/PLT542. CSF protein 88 mg/dL. Clinical Course: The mother of the child had obtained the herbicide from a friend and decanted it into an unmarked soda bottle. At this time it was believed clopyralid was the active ingredient. The patient was observed, managed symptomatically, and discharged home that morning. He returned mid-afternoon the same day after 8 episodes of black emesis. Mother reported his T 40C. In the ED, the patient had abnormal behavior, an unsteady gait, abnormal head movements and was unable to make eye contact, although he was able to answer questions. The patient continued to decompensate and about 4 hours later,family informed providers that the substance ingested was actually an herbicide containing 37% diquat dibromide. BP 118/57, HR 173, RR 34,O2 sat 96% on 2L of O2. He was pale and ataxic, with episodes of diarrhea. He received APAP, ceftriaxone, morphine, prochlorperazine, lorazepam,NS bolus, and an H2-blocker. Head CT was unremarkable. He was admitted to the PICU. He was intubated on arrival and sedated with dexmedetomidine. He was started on NAC. T 39C despite application of a cooling blanket. Cr 3.9 and he was started on CRRT. Intermittent HD was attempted, but he became hemodynamically unstable and required initiation of vasopressors. The patients ventilation status worsened with O2 sat 87 on 100% FiO2. Pressors were increased with minimal improvement of BP. Respiratory viral screen returned positive for rhinovirus,enterovirus and RSV. Chest CT showed bilateral lung infiltrates and thickening of the distal esophageal wall. Stress dose steroids were administered. Lung function continued to worsen and he was started on nitric oxide for ARDS. Hemodynamics and oxygenation continued to worsen,and cyclophosphamide was administered. ECMO, lung transplantation was offered but the patient died despite aggressive resuscitative efforts later on Day 2.
Death
The information for this report was received via an external publication and the summary provided here in Section 13 is directly as written by Gummin et al., 2021. Citation:David D. Gummin, James B. Mowry, Michael C. Beuhler, Daniel A. Spyker, Alvin C. Bronstein, Laura J. Rivers, Nathaniel P. T. Pham Julie Weber (2021) 2020 Annual Report of the American Association of Poison Control Centers National Poison Data System (NPDS): 38th Annual Report, Clinical Toxicology, 59:12, 1282-1501. The exact name of the product was not stated in the publication.