New incident report
Incident Report Number: 2022-1009
Registrant Reference Number: ProPharma Group case #: 2022SCPU00038316
Registrant Name (Full Legal Name no abbreviations): Syngenta Canada Inc.
Address: 140 Research Lane, Research Park
City: Guelph
Prov / State: Ontario
Country: Canada
Postal Code: N1G4Z3
Human
Country: UNITED STATES
Prov / State: UNKNOWN
Unknown
PMRA Registration No. PMRA Submission No. EPA Registration No. Unknown
Product Name: GLYPHOSATE TECHNICAL
Liquid
Unknown
Unknown
Other
Sex: Male
Age: >19 <=64 yrs / >19 <=64 ans
System
Persisted until death
Yes
Yes
3
Day(s) / Jour(s)
Non-occupational
Poisoning from ingestion of the pesticide
Unknown
Oral
Unknown / Inconnu
Unknown / Inconnu
2022SCPU000383016 - Acute glyphosate ingestion: undoubtedly responsible Scenario/Substances: A 47 y/o male drank 1 L of glyphosate because he was feeling sad. He vomited immediately after drinking it and experienced several additional episodes of vomiting and diarrhea overnight. He was unable to tolerate food or water and reported decreased urine output. Past Medical History: Depression Physical Exam: In the ED he was alert and oriented without evidence of trauma. BP 123/84, HR 99, RR 18, O2 Sat 100% on RA, T 37C.Laboratory/Diagnostic Findings: Na 136/K 4.2/Cl 94/CO2 12/BUN 77/Cr9.19/Glu 139/AG 30, lactate 2.7 mmol/L, serum osmolality 319 mOsm/Kg,CK 16,878, AST 354, ALT 424, bilirubin 1.1, INR 0.82, WBC 24.5/Hgb 17.8/Hct 50.4/PLT 330, ABG-pH 7.0/pCO2 49/pO2 536/HCO3 10.1/BE -19.Serum APAP, ethanol, and salicylate not detected. CxR: unremarkable, CTabd/pelvis unremarkable. Clinical Course: In the ED the day after the ingestion he complained of abdominal pain. He developed seizures for which he was given lorazepam and was intubated. He was started on a bicarbonate drip, NAC, and admitted to the ICU. His conditioned worsened with progressive agitation and then obtundation despite being off of any type of sedation. Head CT was consistent with cerebral edema and hypoxic ischemicencephalopathy. He lost his brainstem reflexes and died on Day 3.Autopsy Findings: Antemortem blood: glyphosate 95,000 ng/mL(reporting limit 10 ng/mL). Cause of death: glyphosate toxicity.
Death
The information for this report was received via an external publication and the summary provided in Section 13 is included directly as written by Gummin et al., 2021. Citation:David D. Gummin, James B. Mowry, Michael C. Beuhler, Daniel A. Spyker, Alvin C. Bronstein, Laura J. Rivers, Nathaniel P. T. Pham Julie Weber (2021) 2020 Annual Report of the American Association of Poison Control Centers National Poison Data System (NPDS): 38th Annual Report, Clinical Toxicology, 59:12, 1282-1501. The exact name of the product was not stated in the publication.