Update the report
Incident Report Number: 2021-3169
Registrant Reference Number: USA-BAYERBAH-2021-US0022641 (Report 703812)
Registrant Name (Full Legal Name no abbreviations): Bayer inc
Address: 2920 Matheson Blvd
City: Mississaugua
Prov / State: ON
Country: Canada
Postal Code: L4W 5R6
Domestic Animal
Country: UNITED STATES
Prov / State: UNKNOWN
Unknown
PMRA Registration No. PMRA Submission No. EPA Registration No. 11556-155
Product Name: Seresto collar unknown
Other (specify)
COLLARYes
Other Units: COLLAR
Site: Animal / Usage sur un animal domestique
Unknown
Animal's Owner
Dog / Chien
unknown
1
Female
Unknown
Unknown
Skin
Unknown / Inconnu
Unknown / Inconnu
System
Unknown / Inconnu
Unknown
Unknown
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On an unknown date in approximately 2021, the dog had a seizure and was lethargic, unable to stand, disoriented and died. It is unknown if the dog was examined by a veterinarian or if a necropsy was performed. No more information is expected. This case is closed.
Death
O - Unclassifiable/unassessable The product is not anticipated to cause serious neurological disorders such as seizures and later reported fatal outcome of death after appropriate topical product administration as the controlled release mechanism assures release of only low doses of active ingredient at a time. But seizures were reported in connection with product use in dogs. However, it is known that overdose of 5 collars around the neck of adult dogs for an 8 months period and in 7 week old puppies for a 6 months period did not cause serious signs. This is supported by the extremely low systemic exposure with imidacloprid and flumethrin, particularly during the first week after application and also thereafter. Even with oral product exposure, seizures are not seen. Merely gastrointestinal signs may occur. Any action or treatment may trigger seizures in an animal with a respective disposition. Various etiologies exist for seizure events or paroxysmal signs, e.g. heart disorder, development disorder, metabolic disorder, infection, intoxication, idiopathic epilepsy, trauma, neoplasms. Lethargy is unspecific and may have various other causes. However, lethargy along with other reported neurological disorders are likely associated with seizures. Overall due to limited available information regarding (animal and product details, onset time, state of health, medical history, if the dog was examined by a veterinarian or if a necropsy was performed), a product relation is considered as unassessable.