New incident report
Incident Report Number: 2021-2963
Registrant Reference Number: M-769030-01-1
Registrant Name (Full Legal Name no abbreviations): Bayer CropScience Inc.
Address: Suite 200, 160 Quarry Park Blvd S.E.
City: Calgary
Prov / State: Alberta
Country: Canada
Postal Code: T2C 3G3
Scientific Study
PMRA Registration No. 30219 PMRA Submission No. EPA Registration No.
Product Name: INDAZIFLAM TECHNICAL HERBICIDE
Unknown
Unknown
Title Indaziflam - Short-Term Reproduction Assay with Fathead Minnow (Pimephales promelas)
Date 14-MAY-21
No
Increased health or environmental risk
There was a survival effect on the fish during this study at the test concentration of 0.19 mg/L. The next lowest concentration tested was 0.064 mg/L. This appears to be lower than the current chronic fish NOEC that PMRA is considering in their risk assessments [0.464 mg/L based on fry survival and growth (Banman et al., 2007)] thus would meet the criteria for adverse effects reporting.
No
This study is not considered appropriate for assessing chronic risk to fish. This study is an endocrine screening study, and as such there are a limited number of test concentrations employed and a specific dose-spacing factor and these constraints do not provide for the type of dose-response analysis that lends to a robust risk assessment endpoint. The US EPA has previously acknowledged the limitations of this guideline study type (OCSPP 890.1350) for use in risk assessment. The study by Banman et al. (2007) is more appropriate for a chronic risk assessment for the aquatic environment.