Incident Report

Subform I: General Information

1. Report Type.

New incident report

Incident Report Number: 2019-6023

2. Registrant Information.

Registrant Reference Number: 190140405

Registrant Name (Full Legal Name no abbreviations): Wellmark International

Address: 100 Stone Road West, Suite 111

City: Guelph

Prov / State: Ontario

Country: Canada

Postal Code: N1G5L3

3. Select the appropriate subform(s) for the incident.

Domestic Animal

4. Date registrant was first informed of the incident.

09-AUG-19

5. Location of incident.

Country: CANADA

Prov / State: QUEBEC

6. Date incident was first observed.

09-AUG-19

Product Description

7. a) Provide the active ingredient and, if available, the registration number and product name (include all tank mixes). If the product is not registered provide a submission number.

Active(s)

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PMRA Registration No. 15176      PMRA Submission No.       EPA Registration No.

Product Name: Agricultural Starbar Premium Fly Bait With Muscamone

• Active Ingredient(s)
  • (Z)-9-TRICOSENE
  • METHOMYL

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7. b) Type of formulation.

Application Information

8. Product was applied?

No

9. Application Rate.

10. Site pesticide was applied to (select all that apply).

11. Provide any additional information regarding application (how it was applied, amount applied, the size of the area treated etc).

To be determined by Registrant

12. In your opinion, was the product used according to the label instructions?

Unknown

Subform III: Domestic Animal Incident Report

1. Source of Report

Medical Professional

2. Type of animal affected

Dog / Chien

3. Breed

Australian Shepherd

4. Number of animals affected

1

5. Sex

Female

6. Age (provide a range if necessary )

0.67

7. Weight (provide a range if necessary )

32

lbs

8. Route(s) of exposure

Oral

9. What was the length of exposure?

Unknown / Inconnu

10. Time between exposure and onset of symptoms

<=30 min / <=30 min

11. List all symptoms

System

• Nervous and Muscular Systems
  • Symptom - Muscle trembling

• Gastrointestinal System
  • Symptom - Salivating excessively

• General
  • Symptom - Hyperthermia

• Nervous and Muscular Systems
  • Symptom - Muscle tremors

• Cardiovascular System
  • Symptom - Tachycardia

12. How long did the symptoms last?

Unknown / Inconnu

13. Was medical treatment provided? Provide details in question 17.

Yes

14. a) Was the animal hospitalized?

Yes

14. b) How long was the animal hospitalized?

Unknown

15. Outcome of the incident

Unknown/Inconnu

16. How was the animal exposed?

Accidental ingestion/Ingestion accident.

17. Provide any additional details about the incident

(eg. description of the frequency and severity of the symptoms

On August 9, 2019, the dog was found with the product package in her mouth. Within five minutes, the dog developed trembling and hypersalivation. The owner then took the dog to the regular veterinarian. Shortly after, the dog developed hyperthermia, with a temperature of 104.18 degrees Fahrenheit (F). The regular veterinarian then gave the dog fluids. About ten minutes later, the dog developed tremors and tachycardia, with a heart rate of 160.0 beats per minute (bpm). The regular veterinarian then gave the dog maropitant (Cerenia). The dog was then transfered to an emergency veterinarian who gave methocarbamol (50 milligrams per kilogram (mg/kg)). Soon after, the emergency veterinarian contacted the Animal Product Safety Service (APSS). The APSS veterinarian stated that methomyl (Golden Malrin) is a carbamate that is rapidly absorbed after ingestion, but does not accumulate in the tissues and that it does not "age" on the receptors like organophosphates (OPs) do, so signs are often short-lived. The APSS veterinarian also stated that signs occur within minutes after ingestion, and include salivation, lacrimation, urination, diarrhea, dyspnea, and emesis (SLUDDE) signs, bradycardia, ataxia, weakness, tremors, seizures, and possibly death. Finally, the APSS veterinarian stated that if not a lethal exposure, signs often resolve spontaneously due to the reversible nature of carbamate toxicity. The APSS veterinarian recommended the emergency veterinarian provide fluid therapy, give methocarbamol (continue 0.5-1.0 milliliters (mL) intravenous (IV) at a time until tremors stop, repeat as needed), give diazepam (for tremors, seizures), monitor for central nervous system signs, monitor body temperature, monitor cardiovascular function, give atropine (only for significant bradycardia or bronchial secretions: 0.1-0.2 mg/kg: 1/4-1/3 IV the rest intramuscular (IM) or subcutaneous (SC)), monitor electrolytes (baseline sodium if charcoal is given), give activated charcoal (only if safe to give: 1 mg/kg with sorbitol), provide symptomatic care, provide supportive care, and to call back with questions.

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To be determined by Registrant

18. Severity classification (if there is more than 1 possible classification

Moderate

19. Provide supplemental information here

The bait should not have been anywhere that pets would have access to.