New incident report
Incident Report Number: 2019-3110
Registrant Reference Number: USA-BAYERBAH-2019-US0019652 (Report 561044)
Registrant Name (Full Legal Name no abbreviations): Bayer inc
Address: 2920 Matheson Blvd
City: Mississaugua
Prov / State: ON
Country: Canada
Postal Code: L4W 5R6
Domestic Animal
Country: UNITED STATES
Prov / State: OKLAHOMA
PMRA Registration No. PMRA Submission No. EPA Registration No. 11556-155
Product Name: Seresto Cat (Flumethrin-Imidacloprid) collar
Other (specify)
COLLARYes
Other Units: COLLAR
Site: Animal / Usage sur un animal domestique
Animal's Owner
Cat / Chat
Calico feline
1
Female
7
3.266
kg
Skin
>6 mos <=1 yr / > 6 mois < = 1 an
>6 mos / > 6 mois
System
>3 days <=1 wk / >3 jours <=1 sem
Yes
Yes
Unknown
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On 24 Apr 2019, the cat was vocalizing. On 25 Apr 2019, the cat was examined by a veterinarian; and blood work showed acute renal failure and a urinalysis was positive for blood and abnormally dilute. The cat was administered subcutaneous fluids and released. On 29 Apr 2019, the cat died. No known necropsy was performed. No more information is expected. This case is closed.
Death
N - Unlikely Vocalization is an unspecific sign and may have various other causes. Later diagnosed renal failure, abnormal urinalysis findings and death are not expected following appropriate topical product application as inconsistent with product's pharmacological profile. Oral exposure to the collar is not expected to cause serious signs either. An overdose of 5 collars around the neck was investigated in adult cats and dogs for an 8 months period and in 10 week old kittens and 7 week old puppies for a 6 months period without causing serious signs. This is supported by the extremely low systemic exposure with imidacloprid and flumethrin, particularly during the first week after application and also thereafter. In this case, animal likely died because of renal failure. Time to onset is too long. Other causes must be considered. finally, product relation is considered unlikely.