New incident report
Incident Report Number: 2019-2464
Registrant Reference Number: M-658146-01-1
Registrant Name (Full Legal Name no abbreviations): Bayer CropScience Inc.
Address: Suite 200, 160 Quarry Park Blvd S.E.
City: Calgary
Prov / State: Alberta
Country: Canada
Postal Code: T2C 3G3
Scientific Study
PMRA Registration No. 31450 PMRA Submission No. EPA Registration No.
Product Name: FLUPYRADIFURONE TC
Unknown
Site: Unknown / Inconnu
Unknown
Title Acute Contact Toxicity Test with Flupyradifurone SL 200 with the Solitary Leafcutter Bee(Megachile rotundata L.) in the Laboratory (non-GLP study)
Date 30-APR-19
No
New health or environmental hazard
Acute contact toxicity endpoint (LD50) for a solitary bee species (Megachile rotundata) is 2x lower than previously reported for the honey bee Apis mellifera (PMRA report number 2236691).
No
The observed response of Megachile rotundata is explained by the lack of CYP9Q, CYP9BU, or functional homologues impairing the ability of the organism to efficiently detoxify flupyradifurone. Megachile rotundata is the only species of bee known to date to lack these enzymes and recent efforts by Bayer have demonstrated tolerance of other non-Apis bee species to flupyradifurone (i.e., Bombus terrestris, Osmia bicornis, Osmia cornuta). The potential for Megachile rotundata to be exposed to residue levels of flupyradifurone that are of toxicological concern is expected to be low given the application or timing restrictions on crops that are known to use managed Megachile rotundata.