New incident report
Incident Report Number: 2019-1290
Registrant Reference Number: USA-BAYERBAH-2019-US0003662 (Report 545722)
Registrant Name (Full Legal Name no abbreviations): Bayer inc
Address: 2920 Matheson Blvd
City: Mississaugua
Prov / State: ON
Country: Canada
Postal Code: L4W 5R6
Domestic Animal
Country: UNITED STATES
Prov / State: MARYLAND
PMRA Registration No. PMRA Submission No. EPA Registration No. 11556-155
Product Name: Seresto collar
Other (specify)
COLLARYes
Other Units: COLLAR
Site: Animal / Usage sur un animal domestique
Animal's Owner
Cat / Chat
Domestic Shorthair
1
Male
18
6.8
kg
Skin
>1 mo <= 6 mos / > 1 mois < = 6 mois
>2 mos <=6 mos / > 2 mois < = 6 mois
System
Persisted until death
No
No
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On 01 Dec 2018, the cat exhibited weight loss. On 27 Jan 2019, the cat was anorexic. On 28 Jan 2019, the cat exhibited inappropriate urination once. No medical treatment was sought. On 29 Jan 2019, the cat died. No known necropsy was performed.
Death
N - Unlikely - Reported weight loss is not expected after collar application. Anorexia and inappropriate urination are unspecific signs and may have numerous other causes. Signs are not expected to appear after long time. Later reported death is not expected following appropriate topical product application as inconsistent with product's pharmacological profile. Oral exposure to the collar is not expected to cause death either. An overdose of 5 collars around the neck was investigated in adult cats and dogs for an 8 months period and in 10 week old kittens and 7 week old puppies for a 6 months period without causing serious signs. This is supported by the extremely low systemic exposure with imidacloprid and flumethrin, particularly during the first week after application and also thereafter. No signs of anaphylaxis reported which would have occurred in close proximity to the collar application. Other unrelated causes are more probable in this geriatric cat. Although no necropsy performed, considering long time to onset and overall aspects, a product involvement is considered unlikely.