New incident report
Incident Report Number: 2019-1033
Registrant Reference Number: M-557585-01-1
Registrant Name (Full Legal Name no abbreviations): Bayer CropScience Inc
Address: Suite 200, 160 Quarry Park Blvd S.E.
City: Calgary
Prov / State: Alberta
Country: Canada
Postal Code: T2C 3G3
Scientific Study
PMRA Registration No. PMRA Submission No. EPA Registration No. Unknown
Product Name:
Unknown
Unknown
Title Fenoxaprop-P-ethyl+Thiencarbazone-methyl +Mefenpyr-diethyl EC 117,5 Local Lymph Node Assay in the Mouse
Date 21-JUN-16
No
New health or environmental hazard
Fenoxaprop-P-ethyl + Thiencarbazone-methyl + Mefenpyr diethyl EC 117.5 (80+7.5+30 g/L) was tested in the Local Lymph Node Assay (LLNA) to determine the skin sensitization potential of this formulated pesticide product. Following a preliminary irritation/toxicity test with the test item at 100%, the main test was conducted with 25%, 10% and 5% (w/v) concentrations in 1% aqueous Pluronic PE9200. The test item was applied to both ears of four animals per group on days 1-3, then not applied on days 4-6. Cell proliferation in the local lymph nodes was measured by incorporation of tritiated methyl thymidine and the values obtained were used to calculate stimulation indices (SI). The SI values were 4.3, 1.2 and 1.1 at concentrations of 25%, 10% and 5% test item, respectively. As the highest concentration resulted in an SI value above the threshold of 3.0, and there was a dose response, Fenoxaprop-P-ethyl + Thiencarbazone-methyl + Mefenpyr diethyl EC 117.5 was considered to have skin sensitization potential. The calculated EC3 value is 18.7%.
No