New incident report
Incident Report Number: 2019-0846
Registrant Reference Number: M-413745-01-2
Registrant Name (Full Legal Name no abbreviations): Bayer CropScience Inc
Address: Suite 200, 160 Quarry Park Blvd SE
City: Calgary
Prov / State: AB
Country: Canada
Postal Code: T2C 3G3
Scientific Study
PMRA Registration No. 27526 PMRA Submission No. EPA Registration No.
Product Name: TRIFLOXYSTROBIN TECHNICAL FUNGICIDE
Unknown
Unknown
Title In vitro Chromosome Aberration Test in Chinese Hamster V79 Cells
Date 08-SEP-11
No
New health or environmental hazard
CGA 321113 ((E,E)-methoxyimino-[2-[1-(3-trifluoromethylphenyl)-ethylideneaminooxymethyl]-phenyl]acetic acid [CAS# 252913-85-2]), a plant, livestock, soil, and rat metabolite of trifloxystrobin, was concluded to be clastogenic in an in vitro chromosome aberration assay in V79 cells Chinese hamster at the two highest evaluated concentrations with and without metabolic activation. Cultures were exposed for 4 hours up to 150 g/ml in the absence of S9 mix and up to 600 g/ml in the presence of S9 mix. For both conditions, cells were harvested 18 hours after the beginning of treatment. Cytotoxicity was observed in the absence of S9 at 125 and 150 g/ml and in the presence of S9 from 375 g/ml and above. An increase in aberrations was observed at the two highest evaluated concentratons, 100 and 125 g/ml without S9 and 350 and 400 g/ml in the presence of S9. Only one valid trial was performed in this study.
No
No evidence of genotoxicity was observed in in vitro mutagenicity assays (Ames and HPRT) or in in vivo assays (unscheduled DNA synthesis and mouse micronucleus) on this metabolite. Thus, the overall weight of the evidence indicates that this metabolite is not genotoxic. The reports for the complete set of genotoxicity studies are available upon request.