Incident Report

Subform I: General Information

1. Report Type.

New incident report

Incident Report Number: 2019-0683

2. Registrant Information.

Registrant Reference Number: 190004571

Registrant Name (Full Legal Name no abbreviations): Wellmark International

Address: 100 Stone Road West, Suite 111

City: Guelph

Prov / State: Ontario

Country: Canada

Postal Code: N1G5L3

3. Select the appropriate subform(s) for the incident.

Domestic Animal

4. Date registrant was first informed of the incident.

08-JAN-19

5. Location of incident.

Country: CANADA

Prov / State: ONTARIO

6. Date incident was first observed.

08-JAN-19

Product Description

7. a) Provide the active ingredient and, if available, the registration number and product name (include all tank mixes). If the product is not registered provide a submission number.

Active(s)

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PMRA Registration No. 20118      PMRA Submission No.       EPA Registration No.

Product Name: Starbar Equine Premium Golden Malrin Fly Bait With Muscamone

• Active Ingredient(s)
  • (Z)-9-TRICOSENE
  • METHOMYL

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7. b) Type of formulation.

Application Information

8. Product was applied?

Unknown

9. Application Rate.

10. Site pesticide was applied to (select all that apply).

11. Provide any additional information regarding application (how it was applied, amount applied, the size of the area treated etc).

To be determined by Registrant

12. In your opinion, was the product used according to the label instructions?

Unknown

Subform III: Domestic Animal Incident Report

1. Source of Report

Medical Professional

2. Type of animal affected

Dog / Chien

3. Breed

Biewer Terrier

4. Number of animals affected

1

5. Sex

Female

6. Age (provide a range if necessary )

5.0

7. Weight (provide a range if necessary )

2.9

kg

8. Route(s) of exposure

Oral

9. What was the length of exposure?

Unknown / Inconnu

10. Time between exposure and onset of symptoms

Unknown / Inconnu

11. List all symptoms

System

• Nervous and Muscular Systems
  • Symptom - Muscle tremors

• Gastrointestinal System
  • Symptom - Salivating excessively

• Respiratory System
  • Symptom - Abnormal lung sounds
  • Specify - Respiratory Crackles

• Gastrointestinal System
  • Symptom - Inappropriate defecation

12. How long did the symptoms last?

Unknown / Inconnu

13. Was medical treatment provided? Provide details in question 17.

Yes

14. a) Was the animal hospitalized?

Yes

14. b) How long was the animal hospitalized?

Unknown

15. Outcome of the incident

Fully Recovered / Complètement rétabli

16. How was the animal exposed?

Accidental ingestion/Ingestion accident.

17. Provide any additional details about the incident

(eg. description of the frequency and severity of the symptoms

On January 8, 2019, the owner saw the dog ingest an unknown amount of this product. Soon after, the dog developed tremors, hypersalivation, respiratory crackles (fluid sound in the lungs), and inappropriate defecation. At an unknown date and time, the owner took the dog to the emergency veterinarian. The emergency veterinarian then contacted the Animal Product Safety Service (APSS). The emergency veterinarian stated that dog's heart rate was normal at 100.0 beats per minute (bpm). The APSS veterinarian stated that methomyl is a carbamate that is rapidly absorbed after ingestion, but does not accumulate in the tissues and that it does not "age" on the receptors like organophosphates (OP's) do, so signs are often short-lived. The APSS veterinarian also stated that signs occur within minutes after ingestion, and include salivation, lacrimation, urination, diarrhea, dyspnea, and emesis (SLUDDE) signs, bradycardia, ataxia, weakness, tremors, seizures, and possibly death. Finally, the APSS veterinarian stated that if not a lethal exposure, signs are expected to resolve spontaneously due to the reversible nature of carbamate toxicity. The APSS veterinarian recommended the emergency veterinarian provide fluid therapy, give the dog atropine (0.1 - 0.2 milligrams per kilogram (mg/kg). Give 1/4 of the initial dose intravenous (IV) and the rest intramuscular (IM) or subcutaneously (SQ). The dose can be repeated as needed, but do not over-atropinize the animal. The primary goal of atropine use is to control bradycardia and bronchial secretions.), manage tremors (methocarbamol 50-150 mg/kg IV; Diazepam 0.5-1 mg/kg IV), and to provide oxygen (provide oxygen and ventilatory support as needed for animals in respiratory distress).

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To be determined by Registrant

18. Severity classification (if there is more than 1 possible classification

Moderate

19. Provide supplemental information here

The APSS veterinarian stated that the substance was considered to have a high likelihood of causing the clinical situation. On January 10, 2019, an APSS assistant called to follow up on the case. The emergency veterinary staff stated that on January 8, 2019, the dog was given symptomatic care (fluids, Cerenia/maropitant, methocarbamol, Valium/diazepam, and acepromazine (Ace)) oxygen and activated charcoal. The emergency veterinary staff also stated that on January 9, 2019, the dog's signs resolved and that the dog was released later that afternoon. APSS Case 190004571