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Consumer Product Safety

Incident Report

Subform I: General Information

1. Report Type.

New incident report

Incident Report Number: 2018-6959

2. Registrant Information.

Registrant Reference Number: 180088114

Registrant Name (Full Legal Name no abbreviations): Wellmark International

Address: 100 Stone Road West, Suite 111

City: Guelph

Prov / State: Ontario

Country: Canada

Postal Code: N1G5L3

3. Select the appropriate subform(s) for the incident.

Domestic Animal

4. Date registrant was first informed of the incident.

25-MAY-18

5. Location of incident.

Country: CANADA

Prov / State: ALBERTA

6. Date incident was first observed.

25-MAY-18

Product Description

7. a) Provide the active ingredient and, if available, the registration number and product name (include all tank mixes). If the product is not registered provide a submission number.

Active(s)

PMRA Registration No. 31366      PMRA Submission No.       EPA Registration No.

Product Name: Zodiac Powerspot Flea And Tick Control For Dogs Over 14 kg (30 lbs)

  • Active Ingredient(s)
    • (S)-METHOPRENE
    • PERMETHRIN

7. b) Type of formulation.

Application Information

8. Product was applied?

No

9. Application Rate.

10. Site pesticide was applied to (select all that apply).

11. Provide any additional information regarding application (how it was applied, amount applied, the size of the area treated etc).

To be determined by Registrant

12. In your opinion, was the product used according to the label instructions?

Unknown

Subform III: Domestic Animal Incident Report

1. Source of Report

Animal's Owner

2. Type of animal affected

Cat / Chat

3. Breed

Siamese Cat Mix

4. Number of animals affected

1

5. Sex

Male

6. Age (provide a range if necessary )

3.0

7. Weight (provide a range if necessary )

6.5

kg

8. Route(s) of exposure

Skin

Oral

9. What was the length of exposure?

Unknown / Inconnu

10. Time between exposure and onset of symptoms

Unknown / Inconnu

11. List all symptoms

System

  • Nervous and Muscular Systems
    • Symptom - Fasciculations
    • Symptom - Muscle tremors

12. How long did the symptoms last?

>24 hrs <=3 days / >24 h <=3 jours

13. Was medical treatment provided? Provide details in question 17.

Yes

14. a) Was the animal hospitalized?

Yes

14. b) How long was the animal hospitalized?

Unknown

15. Outcome of the incident

Fully Recovered / Complètement rétabli

16. How was the animal exposed?

Accidental ingestion/Ingestion accident.

17. Provide any additional details about the incident

(eg. description of the frequency and severity of the symptoms

On the morning of May 25, 2018 the cat developed fasciculations (the owner stated he was twitching all over around his mouth and face). A few hours later, the owner contacted the Animal Product Safety Service (APSS). The owner then stated that the only possible exposure could have been when she applied this product to her dog on the night of May 24, 2018. The owner thinks the cat may have rubbed his face on or licked the spot where it was applied on the dog. The APSS veterinarian stated that the risk is for paresthesia that can cause twitching, but central nervous system (CNS) signs can also be seen. The APSS veterinarian further stated that cats do not tolerate permethrin. The APSS veterinarian stated that there are some individual variations in sensitivity and that signs range from mild paresthesia, ataxia and tremors to seizures. The APSS veterinarian continued by stating that signs can develop from almost immediately up to 72 hours post-exposure and that some cats are sensitive enough that casual contact with a treated dog can cause clinical signs. The APSS assistant recommended the owner take the cat to the regular veterinarian and have the veterinarian call for information.


To be determined by Registrant

18. Severity classification (if there is more than 1 possible classification

Moderate

19. Provide supplemental information here

In the afternoon on May 25, 2018, the regular veterinarian called to update the case. The regular veterinarian stated that the cat's mouth was rinsed, methocarbamol (250 milligrams (mg)) was given by mouth (PO)), and a bath was given. The APSS veterinarian recommended the regular veterinarian monitor at a veterinary facility, monitor for CNS signs, give methocarbamol (give another 500 mg PO and monitor response; if tremors are stabilized and the patient is discharged, the owner can give 250 mg three times a day (TID) to help manage the tremors at home), provide fluid diuresis (start intravenous fluids (IVF) if generalized tremors or hyperthermia develops), monitor body temperature, referral to an emergency veterinarian (if tremors worsen), give a bath (to the other cat at home), and to call back with questions. In the evening on May 26, 2018, the regular veterinarian called to discuss the case. The regular veterinarian stated that the owner said that the cat is now having hind end and tail tremors. The APSS veterinarian recommended the owner take the cat to the regular veterinarian and have the regular veterinarian manage tremors (methocarbamol, start with another 50-100 milligrams per kilogram (mg/kg) PO and reassess in an hour; benzodiazpenes can be used adjunctively). On May 29, 2018 the owner called back to update the case. The owner stated that the cat had fully recovered, with signs ending on May 27, 2018.