New incident report
Incident Report Number: 2018-6920
Registrant Reference Number: 180120110
Registrant Name (Full Legal Name no abbreviations): Wellmark International
Address: 100 Stone Road West, Suite 111
City: Guelph
Prov / State: Ontario
Country: Canada
Postal Code: N1G5L3
Domestic Animal
Country: CANADA
Prov / State: NEWFOUNDLAND
PMRA Registration No. 31367 PMRA Submission No. EPA Registration No.
Product Name: Zodiac Powerspot Flea And Tick Control For Dogs Under 14 kg (30 lbs)
No
Unknown
Medical Professional
Dog / Chien
Domestic Unspecified Mix
1
Male
2.0
5.48
kg
Oral
Unknown / Inconnu
>2 hrs <=8 hrs / > 2 h < = 8 h
System
Unknown / Inconnu
Yes
Yes
Unknown
Unknown/Inconnu
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On July 15, 2018, the owner gave 1.0 milliliter (mL) of this product orally. Several hours later, the dog developed tremors. That night, the owner took the dog to the emergency veterinarian. The dog developed mydriasis and his tremors had become moderate. The dog's heart rate was normal at 100 beats per minute (bpm). Soon after, the emergency veterinarian placed an intravenous (IV) catheter and then contacted the Animal Product Safety Service (APSS). The APSS veterinarian stated that the risk is for drooling, vomiting, and oral paresthesia for oral exposures and that rarely in dogs, tremors may be seen when a product with a high concentration of permethrin is given orally. The APSS veterinarian also stated that permethrin is a synthetic pyrethroid insecticide that specifically targets the neurologic system of insects and that it has low toxicity in dogs. The APSS veterinarian further stated that some animals are more sensitive to the ingredients than others. Finally, the APSS veterinarian stated that if ingested there could be hypersalivation and nausea. The APSS veterinarian recommended the emergency veterinarian monitor at the veterinary facility (until normal without medicine (meds) for 6 hours (h)), do not give activated charcoal, provide fluid therapy (intravenous fluids (IVF)), monitor electrolytes, monitor urine color (especially if severe and long lasting tremors; may be at risk for rhabdomyolisis), manage tremors (Methocarbamol dose: pull up 100 milligrams per kilogram (mg/kg) and give to effect. Methocarbamol (Robaxin-V, Fort Dodge, 100 milligrams per milliliter (mg/mL) 20 mL or 100 mL vial): Dogs/cats 55 to 220 mg/kg IV for severe tremor/seizure activity, give 1/2 rapidly (not exceeding 2 milliliters per minute (mL/min)), allow the animal to relax, and then give to effect (repeat to max 330 milligrams per kilogram per day (mg/kg/day)), give diazepam (may need valium or midazolam in conjunction with methocarbamol), monitor for respiratory signs (depression - if exceed the ceiling dose of methocarbamol), monitor for central nervous system (CNS) signs, monitor for gastrointestinal (GI) signs, provide supportive care, manage vomiting (antiemetics as needed), and to call back with questions.
Moderate
This was extra label use of product. This product is labeled for topical applications to dogs.
Medical Professional
Dog / Chien
Domestic Unspecified Mix
1
Male
9.0
5.74
kg
Oral
Unknown / Inconnu
>2 hrs <=8 hrs / > 2 h < = 8 h
System
Unknown / Inconnu
Yes
Yes
Unknown
Unknown/Inconnu
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On July 15, 2018, the owner gave 1.0 milliliter (mL) of this product orally. Several hours later, the dog developed tremors. That night, the owner took the dog to the emergency veterinarian. The dog developed mydriasis and his tremors had become moderate. The dog's heart rate was normal at 100 beats per minute (bpm). Soon after, the emergency veterinarian placed an intravenous (IV) catheter and then contacted the Animal Product Safety Service (APSS). The APSS veterinarian stated that the risk is for drooling, vomiting, and oral paresthesia for oral exposures and that rarely in dogs, tremors may be seen when a product with a high concentration of permethrin is given orally. The APSS veterinarian also stated that permethrin is a synthetic pyrethroid insecticide that specifically targets the neurologic system of insects and that it has low toxicity in dogs. The APSS veterinarian further stated that some animals are more sensitive to the ingredients than others. Finally, the APSS veterinarian stated that if ingested there could be hypersalivation and nausea. The APSS veterinarian recommended the emergency veterinarian monitor at the veterinary facility (until normal without medicine (meds) for 6 hours (h)), do not give activated charcoal, provide fluid therapy (intravenous fluids (IVF)), monitor electrolytes, monitor urine color (especially if severe and long lasting tremors; may be at risk for rhabdomyolisis), manage tremors (Methocarbamol dose: pull up 100 milligrams per kilogram (mg/kg) and give to effect. Methocarbamol (Robaxin-V, Fort Dodge, 100 milligrams per milliliter (mg/mL) 20 mL or 100 mL vial): Dogs/cats 55 to 220 mg/kg IV for severe tremor/seizure activity, give 1/2 rapidly (not exceeding 2 milliliters per minute (mL/min)), allow the animal to relax, and then give to effect (repeat to max 330 milligrams per kilogram per day (mg/kg/day)), give diazepam (may need valium or midazolam in conjunction with methocarbamol), monitor for respiratory signs (depression - if exceed the ceiling dose of methocarbamol), monitor for central nervous system (CNS) signs, monitor for gastrointestinal (GI) signs, provide supportive care, manage vomiting (antiemetics as needed), and to call back with questions.
Moderate
This was an extra label use of product. This product is labeled for topical applications to dogs.