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Consumer Product Safety

Incident Report

Subform I: General Information

1. Report Type.

New incident report

Incident Report Number: 2018-3666

2. Registrant Information.

Registrant Reference Number: 2018CK030

Registrant Name (Full Legal Name no abbreviations): Bayer inc

Address: 2920 Matheson Blvd

City: Mississaugua

Prov / State: ON

Country: Canada

Postal Code: L4W 5R6

3. Select the appropriate subform(s) for the incident.

Domestic Animal

4. Date registrant was first informed of the incident.


5. Location of incident.

Country: CANADA

Prov / State: ONTARIO

6. Date incident was first observed.


Product Description

7. a) Provide the active ingredient and, if available, the registration number and product name (include all tank mixes). If the product is not registered provide a submission number.


PMRA Registration No. 27586      PMRA Submission No.       EPA Registration No.

Product Name: Advantage II Large Cat

  • Active Ingredient(s)

7. b) Type of formulation.

Application Information

8. Product was applied?


9. Application Rate.


Units: mL

10. Site pesticide was applied to (select all that apply).

Site: Animal / Usage sur un animal domestique

11. Provide any additional information regarding application (how it was applied, amount applied, the size of the area treated etc).

15yr 14.8lb fs ragdoll cat was treated with 1 tube of advantage II large cat on april 27th.

To be determined by Registrant

12. In your opinion, was the product used according to the label instructions?


Subform III: Domestic Animal Incident Report

1. Source of Report

Medical Professional

2. Type of animal affected

Cat / Chat

3. Breed


4. Number of animals affected


5. Sex


6. Age (provide a range if necessary )


7. Weight (provide a range if necessary )



8. Route(s) of exposure


9. What was the length of exposure?

>1 wk <=1 mo / > 1 sem < = 1 mois

10. Time between exposure and onset of symptoms

>8 hrs <=24 hrs / > 8 h < = 24 h

11. List all symptoms


  • Skin
    • Symptom - Other
    • Specify - Epidermal collarette
    • Symptom - Lesion
    • Specify - Welt
  • Gastrointestinal System
    • Symptom - Vomiting
  • General
    • Symptom - Lethargy
  • Gastrointestinal System
    • Symptom - Diarrhea

12. How long did the symptoms last?

Unknown / Inconnu

13. Was medical treatment provided? Provide details in question 17.


14. a) Was the animal hospitalized?


14. b) How long was the animal hospitalized?

15. Outcome of the incident


16. How was the animal exposed?

Treatment / Traitement

17. Provide any additional details about the incident

(eg. description of the frequency and severity of the symptoms

on april 28th, the cat was vomiting, depressed, had diarrhea. the cat was examined on may 1st by a veterinarian. epidermal collarettes were found on the pinna, welts were identified on the lower lip. The cat was suspected to have ingested some advantage II from the neck of another cat that was treated at the same time. the cat was treated with steroids and subcutaneous fluids. the attending veterinarian was unsure if the advantage II caused the clinical signs. differential diagnosis included ingestion of an insect in the home or other cause the cat was thought to have recovered at the time of the report

To be determined by Registrant

18. Severity classification (if there is more than 1 possible classification


19. Provide supplemental information here

B - Possible Reported digestive signs are unspecific and may have many potential causes. Diarrheoa is not expected with appropriate product use, however as observed in combination with vomiting and consistent time to onset, product involvement cannot be excluded entirely. Though lethargy is an unspecific sign and may have multiple potential other causes in an animal, it may represent a behavioural response to the product sensation. In this case it may be as a consequence of digestive disorders. Epidermal collarettes on the pinna are not expected with topical product administration. In individual cases hypersensitivity reactions to the product are possible in animals that are particular sensitive. Considering short time to onset, a product involvement is considered to be possible.