New incident report
Incident Report Number: 2018-3662
Registrant Reference Number: 2018CK026
Registrant Name (Full Legal Name no abbreviations): Bayer inc
Address: 2920 Matheson Blvd
City: Mississaugua
Prov / State: ON
Country: Canada
Postal Code: L4W 5R6
Domestic Animal
Country: CANADA
Prov / State: ONTARIO
PMRA Registration No. 27586 PMRA Submission No. EPA Registration No.
Product Name: Advantage II Large Cat
Yes
Units: mL
Site: Animal / Usage sur un animal domestique
Medical Professional
Cat / Chat
Unknown
2
Unknown
Unknown
10.9
kg
Skin
>8 hrs <= 24 hrs / >8 h <= 24 h
>8 hrs <=24 hrs / > 8 h < = 24 h
System
>8 hrs <=24 hrs / > 8 h < = 24 h
Yes
Yes
1
Day(s) / Jour(s)
Fully Recovered / Complètement rétabli
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
24hrs later, both cats showed tremors, a seizure, dilated pupils and were hyper-reactive. the cats were treated with iv fluids, methocarbamol, diazepam and given a dish soap bath. the cats have received advantage II previous with no issues. The veterinary clinic suspected permethrin toxicity. at the time of the report the cats were recovered. Note: Previous applications were well tolerated.
Moderate
O - Unclassifiable/unassessable Serious nervous system disorders such as seizures are not anticipated with topical administration of Advantage II. From a toxicological point of view, neither imidacloprid nor pyriproxyfen does have the potential to provoke seizures in vertebrates. In case of oral ingestion of a considerable amount of product or after administration of an overdose shortly after product application, neurological symptoms such as tremor, ataxia, depression, miosis or mydriasis may occur. But seizures are not expected. Also, previous applications were well tolerated. The veterinary clinic suspected permethrin toxicity and treated as such. Thus, they suspected other product was used for treatment. Other reported signs likely associated with the reported seizure. Considering short time to onset, a product relation is considered unassessable.