New incident report
Incident Report Number: 2018-2719
Registrant Reference Number: USA-BAYERBAH-2018-US0031282 (Report 497186)
Registrant Name (Full Legal Name no abbreviations): Bayer inc
Address: 2920 Matheson Blvd
City: Mississaugua
Prov / State: ON
Country: Canada
Postal Code: L4W 5R6
Domestic Animal
Country: UNITED STATES
Prov / State: LOUISIANA
Unknown
PMRA Registration No. PMRA Submission No. EPA Registration No. Unknown
Product Name: advantageII pipette size unknown
Other (specify)
spot onYes
Unknown
Site: Animal / Usage sur un animal domestique
Unknown
Animal's Owner
Cat / Chat
Siamese
1
Female
2
2.041
kg
Skin
Unknown / Inconnu
>2 hrs <=8 hrs / > 2 h < = 8 h
System
Persisted until death
No
No
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
Approximately 6 hours post application, the cat exhibited eye color change from blue to green (Iris disorder nos). The cat was not evaluated by a veterinarian, no treatments were performed and the clinical sign continued. On an unspecified date in 2013, post application, the cat died. No necropsy was performed. Due to the sensitive nature of the communication, specific relevant event details were not obtained, nor will such be sought. The reason for the initial communication was to discuss use of the product and not to report the death in this event. No more information is expected and this case is closed.
Death
N - Unlikely Reported eye color change after topical product administration is not anticipated. No ocular exposure is reported. The level of information is extremely low. Nevertheless death is inconsistent with pharmaco-toxicological product profile and experience. No signs of allergic/anaphylactic reaction reported. Product has wide margin of safety. Oral LD50 in rat is 642 mg/kg BW. 24-fold overdosage tolerated by cats without showing any side effect. The reason for the initial communication was to discuss use of the product and not to report the death in this event. Though, time to onset is short for initial reported sign, it is unknown for death. In case suspected product involvement adverse event would have been reported in close proximity and not long time after. Even though no necropsy is available, sufficient information exists to rule out product relation completely. Overall, a product relation is consider as unlikely