Incident Report

Subform I: General Information

1. Report Type.

New incident report

Incident Report Number: 2017-7594

2. Registrant Information.

Registrant Reference Number: 170189044

Registrant Name (Full Legal Name no abbreviations): Wellmark International

Address: 100 Stone Road West, Suite 111

City: Guelph

Prov / State: Ontario

Country: Canada

Postal Code: N1G5L3

3. Select the appropriate subform(s) for the incident.

Domestic Animal

4. Date registrant was first informed of the incident.

29-OCT-17

5. Location of incident.

Country: CANADA

Prov / State: ONTARIO

6. Date incident was first observed.

28-OCT-17

Product Description

7. a) Provide the active ingredient and, if available, the registration number and product name (include all tank mixes). If the product is not registered provide a submission number.

Active(s)

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PMRA Registration No. 31366      PMRA Submission No.       EPA Registration No.

Product Name: Zodiac Powerspot Flea And Tick Control For Dogs Over 14 kg (30 lbs)

• Active Ingredient(s)
  • (S)-METHOPRENE
  • PERMETHRIN

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7. b) Type of formulation.

Application Information

8. Product was applied?

Yes

9. Application Rate.

2

Units: mL

10. Site pesticide was applied to (select all that apply).

Site: Animal / Usage sur un animal domestique

11. Provide any additional information regarding application (how it was applied, amount applied, the size of the area treated etc).

On October 27, 2017 the owner accidentally applied the dog product to the cat.

To be determined by Registrant

12. In your opinion, was the product used according to the label instructions?

No

Subform III: Domestic Animal Incident Report

1. Source of Report

Animal's Owner

2. Type of animal affected

Cat / Chat

3. Breed

Domestic Shorthair

4. Number of animals affected

1

5. Sex

Male

6. Age (provide a range if necessary )

5.5

7. Weight (provide a range if necessary )

8.2

kg

8. Route(s) of exposure

Skin

9. What was the length of exposure?

Unknown / Inconnu

10. Time between exposure and onset of symptoms

>8 hrs <=24 hrs / > 8 h < = 24 h

11. List all symptoms

System

• General
  • Symptom - Hiding
  • Symptom - Vocalizing

• Skin
  • Symptom - Pruritus

• General
  • Symptom - Abnormal behaviour
  • Specify - Behavior Change

• Skin
  • Symptom - Hyperesthesia

• Nervous and Muscular Systems
  • Symptom - Agitation

• Skin
  • Symptom - Erythema

12. How long did the symptoms last?

Unknown / Inconnu

13. Was medical treatment provided? Provide details in question 17.

Yes

14. a) Was the animal hospitalized?

Unknown

14. b) How long was the animal hospitalized?

15. Outcome of the incident

Not recovered / Non rétabli

16. How was the animal exposed?

Treatment / Traitement

17. Provide any additional details about the incident

(eg. description of the frequency and severity of the symptoms

On October 28, 2017, the cat developed hiding, vocalization, pruritus, and a behavioral change (does not want to be touched, gets a bit aggressive). On October 29, 2017 the owner contacted the Animal Product Safety Service (APSS). A few hours following the call, the cat developed hyperesthesia, agitation, and erythema (at the application site). The APSS veterinarian stated that cats do not tolerate permethrin and that variations in sensitivity depend on the individual. The APSS veterinarian also stated that the risks are for ataxia, tremors, agitation, facial and ear twitching, seizures, hyperthermia, and potentially death if untreated. Finally, the APSS veterinarian stated that signs can develop from almost immediately up to 72 hours post-exposure and that some cats are sensitive enough that casual contact with a treated dog can cause clinical signs. The APSS veterinarian recommended the owner take the cat to a veterinarian, have the veterinarian call for information, and to call back with questions.

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To be determined by Registrant

18. Severity classification (if there is more than 1 possible classification

Moderate

19. Provide supplemental information here

This was an inappropriate use of a dog product on to the cat. In the evening on October 29, 2017 the emergency veterinarian called for information. The APSS veterinarian recommended the emergency veterinarian give the cat a bath (Dawn, total body, lather, rinse and repeat), provide vitamin E (apply to application site), give corticosteroid, give diphenhydramine, give maropitant (as needed), monitor for tremors (for another 24 hrs), provide symptomatic care (if tremors develop: methocarbamol. Intralipids if signs are not easily controlled), and provide supportive care. On November 3, 2017 an APSS assistant contacted the owner to follow up on the case. The owner stated that the cat is doing better but signs still continue.