Incident Report

Subform I: General Information

1. Report Type.

New incident report

Incident Report Number: 2017-7038

2. Registrant Information.

Registrant Reference Number: 170099985

Registrant Name (Full Legal Name no abbreviations): Wellmark International

Address: 100 Stone Road West, Suite 111

City: Guelph

Prov / State: Ontario

Country: Canada

Postal Code: N1G5L3

3. Select the appropriate subform(s) for the incident.

Domestic Animal

4. Date registrant was first informed of the incident.

15-JUN-17

5. Location of incident.

Country: CANADA

Prov / State: ONTARIO

6. Date incident was first observed.

14-JUN-17

Product Description

7. a) Provide the active ingredient and, if available, the registration number and product name (include all tank mixes). If the product is not registered provide a submission number.

Active(s)

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PMRA Registration No. 31366      PMRA Submission No.       EPA Registration No.

Product Name: Zodiac Powerspot Flea and Tick Control For Dogs Over 14 kg (30 lbs)

• Active Ingredient(s)
  • (S)-METHOPRENE
  • PERMETHRIN

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7. b) Type of formulation.

Application Information

8. Product was applied?

Yes

9. Application Rate.

2

Units: mL

10. Site pesticide was applied to (select all that apply).

Site: Animal / Usage sur un animal domestique

11. Provide any additional information regarding application (how it was applied, amount applied, the size of the area treated etc).

On June 14, 2017 the owner accidentally applied the dog product to the cat.

To be determined by Registrant

12. In your opinion, was the product used according to the label instructions?

No

Subform III: Domestic Animal Incident Report

1. Source of Report

Medical Professional

2. Type of animal affected

Cat / Chat

3. Breed

Domestic Shorthair

4. Number of animals affected

1

5. Sex

Female

6. Age (provide a range if necessary )

5.0

7. Weight (provide a range if necessary )

12.0

lbs

8. Route(s) of exposure

Skin

9. What was the length of exposure?

Unknown / Inconnu

10. Time between exposure and onset of symptoms

>8 hrs <=24 hrs / > 8 h < = 24 h

11. List all symptoms

System

• Nervous and Muscular Systems
  • Symptom - Muscle tremors

• Cardiovascular System
  • Symptom - Tachycardia

12. How long did the symptoms last?

>8 hrs <=24 hrs / > 8 h < = 24 h

13. Was medical treatment provided? Provide details in question 17.

Yes

14. a) Was the animal hospitalized?

Yes

14. b) How long was the animal hospitalized?

Unknown

15. Outcome of the incident

Fully Recovered / Complètement rétabli

16. How was the animal exposed?

Treatment / Traitement

17. Provide any additional details about the incident

(eg. description of the frequency and severity of the symptoms

Later in the afternoon on June 14, 2017, the cat developed symptoms. The owner then wiped off the cat's coat with a wet cloth. On June 15, 2017 the tremors had worsened. The owner then gave the cat a bath (without using any soap) and took the cat to a veterinarian. The regular veterinarian then administered fluids (with valium and acepromazine). A few hours later, the regular veterinarian contacted the Animal Product Safety Service (APSS). The APSS veterinarian stated that cats do not tolerate permethrin and that there are some individual variations in sensitivity. The APSS veterinarian also stated that signs range from mild paresthesia, ataxia and tremors to seizures and that signs can develop from almost immediately up to 72 hours post-exposure. The APSS veterinarian further stated that some cats are sensitive enough that casual contact with a treated dog can cause clinical signs. Finally, the APSS veterinarian stated that as long as signs are controlled, prognosis is good. The APSS veterinarian recommended the regular veterinarian bathe the cat (using liquid dish washing detergent (LDWD), give methocarbamol (first dose 50-75 milligrams per kilogram (mg/kg), either by intravenous (IV) injection or per rectum; can add about 30 mg/kg increment after an hour if still marked tremors; keep running tally on total dose in mg/kg), provide thermoregulation (keep warm, becoming hypothermic will potentiate the pyrethroid signs), monitor at the veterinary facility, provide fluid therapy (consider IV fluids if marked tremors, concern for myoglobinuria damaging renal tubules), and to call back with questions.

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To be determined by Registrant

18. Severity classification (if there is more than 1 possible classification

Moderate

19. Provide supplemental information here

On June 16, 2017 the APSS veterinarian called to follow up on the case. The regular veterinarian stated that the cat was doing well and asked if the cat needed another bath. The APSS veterinarian stated that if the cat is doing well, another bath is not needed. This was off label use, applying the dog product on to the cat.