New incident report
Incident Report Number: 2017-3267
Registrant Reference Number: USA-BAYERBAH-2015-US0061880
Registrant Name (Full Legal Name no abbreviations): Bayer inc
Address: 2920 Matheson Blvd
City: Mississaugua
Prov / State: ON
Country: Canada
Postal Code: L4W 5R6
Domestic Animal
Country: UNITED STATES
Prov / State: ALABAMA
Unknown
PMRA Registration No. PMRA Submission No. EPA Registration No. Unknown
Product Name: Advantage II unspecified size
Other (specify)
Spot-onYes
Unknown
Site: Animal / Usage sur un animal domestique
Unknown
Animal's Owner
Cat / Chat
Unknown
1
Unknown
Unknown
Unknown
Skin
Unknown / Inconnu
Unknown / Inconnu
System
Unknown / Inconnu
No
No
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On an unspecified date in approximately 2012, a feline of unknown signalment and condition, with no known concurrent medical conditions, was administered 1 tube of Advantage II (cat-unspecified) (Imidacloprid-Pyriproxyfen) topically by the owner. On an unknown date post application, in approximately 2012, the cat died. No necropsy was performed. The reporting party did not contact Bayer Animal Health to report the death of the animal but to discuss the product. Due to the nature of the communication and in order to avoid further strain on the relationship with the reporting party, no further information will be sought. No more information is expected. Case is closed.
Death
Death is not expected after product application, as inconsistent with pharmaco-toxicological product profile. No signs of allergic/anaphylactic reaction reported in close proximity of product application. Product has wide margin of safety. Oral LD50 in rat 642 mg/kg BW. 24-fold overdosage tolerated by cats without showing any side effect. Moreover in case of suspected product involvement, adverse event would have been reported in close proximity and not long time after. The information regarding the death of the cat was casually provided during an inquiry as the reporting party did not contact Bayer Animal Health to report the death of the animal but to inquire about additional product applications. unlikely to be related