New incident report
Incident Report Number: 2016-4262
Registrant Reference Number: 2016KP143
Registrant Name (Full Legal Name no abbreviations): Bayer Inc
Address: 2920 matheson BLVD
City: Mississaugua
Prov / State: ON
Country: Canada
Postal Code: L4W 5R6
Domestic Animal
Country: UNITED STATES
Prov / State: UNKNOWN
PMRA Registration No. PMRA Submission No. EPA Registration No. 11556-155
Product Name: Seresto Collar - Cat
Other (specify)
collarYes
Other Units: collar
Site: Animal / Usage sur un animal domestique
Other
Cat / Chat
Persian
1
Male
1
Unknown
Skin
>1 wk <=1 mo / > 1 sem < = 1 mois
>1 wk <=1 mo / > 1 sem < = 1 mois
System
>24 hrs <=3 days / >24 h <=3 jours
Yes
Yes
2
Day(s) / Jour(s)
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On 13 Oct 2015, the feline had liquid diarrhea. On 14 Oct 2015, the feline vomited several times. It was fed water through a syringe orally by the owner and would drool and foam at the mouth after administration of the water. The diarrhea continued. The feline was examined by the attending veterinarian. Unknown tests were performed and they were within normal limits. The feline was hospitalized. It was administered an unknown dose of maropitant citrate . The Seresto collar was tightened by the attending veterinarian but the cat continued to have fleas. On 15 Oct 2015, the feline continued to vomit and have diarrhea. It behaved quieter than normal (lethargy). The collar was removed by the attending veterinarian. The cat remained hospitalized but treatments were not specified. On 16 Oct 2015, a fecal exam was positive for coccidia, and the feline was started on an unknown dose of sulfadimethoxine orally by the attending veterinarian. The feline was not eating or drinking and developed bloody diarrhea and blood was also present in the cat's vomitus. The feline developed cardiac and respiratory arrest and died. Follow up information received on 31st may 2016 : No known necropsy was performed. No further information expected. Case closed.
Death
Digestive signs are unspecific and may have numerous other causes (e.g. gastrointestinal infection, dietary incompatibility and concomitant conditions). No oral product exposure. Reported systemic signs are unspecific, however in this case these are likely consequence of digestive disorders. Adipsia is not expected however, it is likely associate with anorexia. Serious signs like cardiac and respiratory arrest are not expected after topical application of the product. Death is not expected following appropriate topical product application as inconsistent with products pharmacological profile. Oral exposure to the collar is not expected to cause death either. No signs of anaphylaxis reported which would have occurred in close proximity to the collar application. Death was the consequence of serious signs (cardiac and respiratory arrest), moreover serious signs were observed after removal of collar. Considering the safety profile of the product, very long time to onset and though no necropsy was done sufficient information exists to rule out product involvement and relation remains unlikely.