New incident report
Incident Report Number: 2015-6136
Registrant Reference Number: 2015KP253
Registrant Name (Full Legal Name no abbreviations): Bayer Inc
Address: 2920 Matheson Blvd. East
City: Mississauga
Prov / State: ON
Country: Canada
Postal Code: L4W 5R6
Domestic Animal
Country: UNITED STATES
Prov / State: UNKNOWN
PMRA Registration No. PMRA Submission No. EPA Registration No. 11556-151
Product Name: Advantage II Small cat
Liquid
Yes
Units: mL
Site: Animal / Usage sur un animal domestique
Unknown
Other
Cat / Chat
Domestic Shorthair
1
Female
4
10
lbs
Skin
>1 wk <=1 mo / > 1 sem < = 1 mois
>1 wk <=1 mo / > 1 sem < = 1 mois
System
Unknown / Inconnu
No
No
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On 03 Jul 2015, the cat died and was taken to the veterinary clinic. The attending veterinarian deemed the death was due to flea bite anemia. No necropsy was performed. The purpose of the call to Bayer Animal Health was not to report the death of this patient but to discuss the use of another product on a dog in the home. No more information is expected. Case is closed.
Death
The information regarding the death of the cat was casually provided during an inquiry. The purpose of the call to Bayer Animal Health was not to report the death of this patient but to discuss the use of another product on a dog in the home. Nevertheless death is inconsistent with pharmaco-toxicological product profile and experience. No signs of allergic/anaphylactic reaction reported. Product has wide margin of safety. Oral LD50 in rat 642 mg/kg BW. 24-fold overdosage tolerated by cats without showing any side effect. Time to onset is too long for a product relation. The death of this cat was deemed due to the flea bite anemia. Flea bite anemia is not expected either and regular treatments for at least a 6-week period are necessary in order to break the flea development circle. Considering all aspects, a product connection is deemed to be unlikely.