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Consumer Product Safety

Incident Report

Subform I: General Information

1. Report Type.

New incident report

Incident Report Number: 2013-6594

2. Registrant Information.

Registrant Reference Number: A130094254

Registrant Name (Full Legal Name no abbreviations): Dow AgroSciences Canada Inc.

Address: Suite 2100, 450 - 1 Street S.W.

City: Calgary

Prov / State: Alberta

Country: Canada

Postal Code: T2P 5H1

3. Select the appropriate subform(s) for the incident.

Domestic Animal

4. Date registrant was first informed of the incident.

11-JUL-13

5. Location of incident.

Country: UNITED STATES

Prov / State: KANSAS

6. Date incident was first observed.

10-JUL-13

Product Description

7. a) Provide the active ingredient and, if available, the registration number and product name (include all tank mixes). If the product is not registered provide a submission number.

Active(s)

PMRA Registration No.       PMRA Submission No.       EPA Registration No. 62719--519

Product Name: Milestone

  • Active Ingredient(s)
    • AMINOPYRALID
      • Guarantee/concentration 40.6

7. b) Type of formulation.

Liquid

Application Information

8. Product was applied?

Yes

9. Application Rate.

4

Other Units: per acre

10. Site pesticide was applied to (select all that apply).

Site: Agricultural-Outdoor/Agricole-extérieur

Préciser le type: pasture

11. Provide any additional information regarding application (how it was applied, amount applied, the size of the area treated etc).

The farmer used this product in his field this spring to control thistles. He started application in mid May and it took about 1 month for him to finish the process.

To be determined by Registrant

12. In your opinion, was the product used according to the label instructions?

Unknown

Subform III: Domestic Animal Incident Report

1. Source of Report

Medical Professional

2. Type of animal affected

Cow / Vache

3. Breed

Angus Cattle group of 2 (Bovine)

4. Number of animals affected

2

5. Sex

Male

6. Age (provide a range if necessary )

0

7. Weight (provide a range if necessary )

Unknown

8. Route(s) of exposure

Unknown

9. What was the length of exposure?

>1 wk <=1 mo / > 1 sem < = 1 mois

10. Time between exposure and onset of symptoms

>1 wk <=1 mo / > 1 sem < = 1 mois

11. List all symptoms

System

  • General
    • Symptom - Death

12. How long did the symptoms last?

Unknown / Inconnu

13. Was medical treatment provided? Provide details in question 17.

Unknown

14. a) Was the animal hospitalized?

Unknown

14. b) How long was the animal hospitalized?

15. Outcome of the incident

Died

16. How was the animal exposed?

Other / Autre

specify pregnant cow ingested treated thistle

17. Provide any additional details about the incident

(eg. description of the frequency and severity of the symptoms

The farmer had two calves die in the past week. Both calves apparently died at birth or shortly after. The cows did eat the thistles after application of the product and he is concerned that the herbicide may have played a part in the deaths since it is rare to have two calves die at birth. The caller says the field was fertilized with nitrates as well.


To be determined by Registrant

18. Severity classification (if there is more than 1 possible classification

Death

19. Provide supplemental information here

There are no grazing restrictions listed on the label, so we would not expect this symptom to occur if the product was used per label. What we can see with herbicide use is that some toxic plants can become more palatable and more toxic after treatment with an herbicide. Russian Thistle accumulates nitrates and may become more toxic and palatable during wilting. In cattle, nitrates can result in Methb, which can result in fetal/infant death due to hypoxia. Because the time course was somewhat consistent, the amount was unknown consistent, and the findings were poorly consistent, this substance was considered to have doubtful likelihood of causing the clinical situation.