New incident report
Incident Report Number: 2013-6462
Registrant Reference Number: 130125184
Registrant Name (Full Legal Name no abbreviations): Wellmark International
Address: 100 Stone Road West, Suite 111
City: Guelph
Prov / State: Ontario
Country: Canada
Postal Code: N1G5L3
Domestic Animal
Country: UNITED STATES
Prov / State: VERMONT
PMRA Registration No. PMRA Submission No. EPA Registration No. 2724-504
Product Name: Zodiac Spot On Plus Flea And Tick Control For Cats 5lbs and over
Liquid
Yes
Units: mL
Site: Animal / Usage sur un animal domestique
Medical Professional
Cat / Chat
Domestic Shorthair
1
Male
6.5
12.1
lbs
Skin
>8 hrs <= 24 hrs / >8 h <= 24 h
<=30 min / <=30 min
System
Persisted until death
No
No
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On September 5, 2013, immediately after the product was applied to the cat, the owner noticed that the cat was hiding. On the morning of September 6, 2013 the owner noticed that the cat had dyspnea, and the died in the car as the owner was taking the cat to the veterinarian. Later that morning the owner's regular veterinarian contacted the Animal Product Safety Service (APSS) to obtain help. The APSS veterinarian stated that death would not be expected. The APSS veterinarian recommended a necropsy and faxed the necessary forms to the clinic.
Death
The APSS veterinarian stated that the substance was considered to have a doubtful likelihood of causing the clinical situation. On September 9, 2013 an APSS assistant called the owner's regular veterinarian to check on the status of the necropsy; the owner's regular veterinarian stated that the body had been shipped to the diagnostic lab earlier that morning. On September 19, 2013 an APSS technician recorded the interim necropsy results in the case. The heart revealed left ventricular hypertrophy and the bone marrow revealed diffuse chronic hamatopiesis. A cause of death was not yet determined, but left ventricular hypertrophy (hypertrophic cardiomyopathy) syndrome could be a possibility; the bone marrow was likely responding to anemia; the hair seen in the digestive tract could be secondary to over-grooming after application of the topical flea product. Samples were collected for histopathology, toxicology, and appropriate ancillary testing; results are pending. The necropsy was not able to specify the cause of death, However, chronic hemorrhages in the brain suggest previous injury likely stroke and could be clinically significant