New incident report
Incident Report Number: 2013-6263
Registrant Reference Number: 2013CK011
Registrant Name (Full Legal Name no abbreviations): Bayer Inc
Address: 77 Belfield Rd
City: Toronto
Prov / State: ON
Country: Canada
Postal Code: M9W 1G6
Domestic Animal
Country: UNITED STATES
Prov / State: UNKNOWN
PMRA Registration No. PMRA Submission No. EPA Registration No.
Product Name: Advantage 18
Liquid
Yes
Units: mL
Site: Animal / Usage sur un animal domestique
Unknown
Animal's Owner
Cat / Chat
Domestic short hair
1
Female
17
12
lbs
Skin
Unknown / Inconnu
Unknown / Inconnu
System
Persisted until death
No
No
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On approximately 01-Sep-2009, a 17 year old, 12 pound, spayed, female, Domestic Shorthair feline, in poor condition, with a known medical history of an unknown cancer, was administered 1 tube of Advantage 18 Topical Solution (Imidacloprid) once topically by the owner. This cat was receiving an unknown regimen of chemo therapy prior to death as well. It is unknown when the last chemo therapy treatment was preformed. On approximately 30-Sep-2009 the cat passed away at home. The cat was not examined or treated by a veterinarian. No necropsy was preformed. The owner original contacted Bayer Animal Health to discuss expiration dates of current product on hand, not to report the death of this pet.
Death
The information regarding the death of the cat was casually provided during an inquiry. Reporting of occurrence 4 years after product application. Nevertheless cancer resulting in death is not expected as inconsistent with pharmacotoxicological product profile and experience. Product has wide margin of safety. Oral LD50 in rat 642 mg/kg BW. 24- fold overdosage tolerated by cats without showing any side effect. Death occured one month after last product exposure, therefore inconsistent chronology. The cause of death of this geriatric cat is probably due to the underlying disease (cancer) according to case description. No reaction on previous exposure. Finally, a product relation can be completely excluded.