New incident report
Incident Report Number: 2013-4530
Registrant Reference Number: 2013AM209
Registrant Name (Full Legal Name no abbreviations): Bayer Inc
Address: 77 Belfield Rd
City: Toronto
Prov / State: ON
Country: Canada
Postal Code: M9W 1G6
Domestic Animal
Country: UNITED STATES
Prov / State: UNKNOWN
Unknown
PMRA Registration No. PMRA Submission No. EPA Registration No. 11556-151
Product Name: Advantage II small cat
Liquid
Yes
Units: mL
Site: Animal / Usage sur un animal domestique
Animal's Owner
Cat / Chat
unknown
1
Unknown
20
Unknown
Skin
Unknown / Inconnu
Unknown / Inconnu
System
Persisted until death
Unknown
Unknown
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On an unknown date, a 20 year old, feline, of unknown signalment, in unknown condition, with no known concomitant medical conditions, was administered 1 tube of Advantage II Small Cat (Imidacloprid-Pyriproxyfen) once topically by the owner. On an unknown date in 2013 the cat had trouble breathing. The veterinarian was called and the cat was taken in. The cat died, it is unknown if he died before veterinarian examination. It is unknown if a necropsy was performed. The communication was to inquire about another cat in the house, not to report this event.
Death
Intended direct topical dermal exposure of the product to the cat. Abnormal breathing resulting in death is unlikely productrelated as inconsistent with the pharmacological and toxicological product profile. Product has wide margin of safety. Oral LD50 in rat 642 mg / kg BW. 24-fold overdosage tolerated by cats without showing any side effect. Other etiologies have to be considered. Unknown duration to onset time. Unknown death cause according to case description. Nevertheless, death is unlikely related to application of the product.