New incident report
Incident Report Number: 2013-3092
Registrant Reference Number: 2013AM092
Registrant Name (Full Legal Name no abbreviations): Bayer Inc
Address: 77 Belfield Rd
City: Toronto
Prov / State: ON
Country: Canada
Postal Code: M9W 1G6
Domestic Animal
Country: UNITED STATES
Prov / State: UNKNOWN
Unknown
PMRA Registration No. PMRA Submission No. EPA Registration No. 11556-152
Product Name: Advantage 18
Liquid
Yes
Units: mL
Site: Animal / Usage sur un animal domestique
Animal's Owner
Cat / Chat
Domestic short hair
1
Male
4
Unknown
Skin
Unknown / Inconnu
Unknown / Inconnu
System
Unknown / Inconnu
Unknown
Unknown
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On approximately 01-Sep-2010, the owner of a 4 year old, unknown weight, neutered, male, Domestic Shorthair feline, in good condition, with no known concomitant medical conditions, removed 1 tube of Advantage 18 (Imidacloprid-Pyriproxyfen) from the package to apply to the cat. The cat immediately ran and hid (abnormal behavior). The owner then caught the cat and applied the product. The cat then went outside and, approximately 4 hours later, came back inside completely recovered. No treatments or exam by a veterinarian were required. On 02-Jan-2011 the cat was found in the yard deceased. No necropsy was performed.
Death
The initial behavioural disorder by running away and hide might have been a behavioural response to the product sensation/smell. However death reported is not expected after product application as inconsistent with pharmacotoxicological product profile. Duration to onset time over 4 month too long. Also product has wide margin of safety. Oral LD50 in rat 642 mg / kg BW. 24-fold overdosage tolerated by cats without showing any side effects. Unknown death cause in this report decribed. However, based on product profile, and very long time to onset for fatal outcome, product relation is considered unlikely.