New incident report
Incident Report Number: 2013-3070
Registrant Reference Number: 2013AM079
Registrant Name (Full Legal Name no abbreviations): Bayer Inc
Address: 77 Belfield Rd
City: Toronto
Prov / State: ON
Country: Canada
Postal Code: M9W 1G6
Domestic Animal
Country: UNITED STATES
Prov / State: UNKNOWN
PMRA Registration No. PMRA Submission No. EPA Registration No. Unknown
Product Name: Advantage (Dog)
Liquid
Yes
Unknown
Site: Animal / Usage sur un animal domestique
No
Animal's Owner
Cat / Chat
Domestic Shorthair
1
Female
7
4
lbs
Skin
>15 min <=2 hrs / >15 min <=2 h
>30 min <=2 hrs / >30 min <=2 h
System
Persisted until death
No
No
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
30 minutes post application the cat fell down the stairs, was staggering, and then had a seizure. The owner then removed the duct tape and realized it was dog product. The owner contacted her veterinarian and was advised to bathe the cat, which she did. 2 days later the cat passed away. No necropsy was performed.
Death
Serious nervous system disorders such as seizures are not anticipated with topical administration of Advantage. From a toxicological point of view, imidacloprid or pyriproxyfen do not have potential to provoke seizures in vertebrates. In case of oral ingestion of considerable amount of product or after administration of overdose, mild neurological signs such as tremor, ataxia, depression, miosis or mydriasis may occur. But seizures and fatal not expected, as inconsistent with pharmaco-toxicological product profile. Unknown if onset time of staggering before cat fell down stairs. Seizures started after cat fell down stairs and therefore other etiologies more likely. Cat very light weight, indicating underlying disease. Though time to onset close and chronology short, product application and occurrence of signs considered merely co-incidental. Thus, overall product involvement with fatal outcome considered unlikely.