New incident report
Incident Report Number: 2013-3047
Registrant Reference Number: 2013AM117
Registrant Name (Full Legal Name no abbreviations): Bayer Inc
Address: 77 Belfield Rd
City: Toronto
Prov / State: ON
Country: Canada
Postal Code: M9W 1G6
Domestic Animal
Country: UNITED STATES
Prov / State: UNKNOWN
PMRA Registration No. PMRA Submission No. EPA Registration No. 11556-144
Product Name: K9 Advantix II Large dog
Liquid
Yes
Units: mL
Site: Animal / Usage sur un animal domestique
Animal's Owner
Dog / Chien
French Bulldog
1
Male
6
33
lbs
Skin
>8 hrs <= 24 hrs / >8 h <= 24 h
>8 hrs <=24 hrs / > 8 h < = 24 h
System
Unknown / Inconnu
Yes
Yes
24
Hour(s) / Heure(s)
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On 07-Jan-2013, the patient began vomiting, having diarrhea, was weak, had dilated pupils, and was circling. On 08-Jan-2013, the owner bathed the patient with a baby shampoo. The dog was taken to the veterinary clinic where they performed an examination and administered atropine sulfate. Follow up of 21-Jan-2013: The dog was hospitalized overnight and IV fluids (unspecified) was given. On 09 Jan 2013 the owner declined treatments and diagnostics suggested by the DVM due to financial concerns and the dog was taken home by the owner. On the same day the dog had seizures and died of unknown causes. No necropsy was performed.
Death
Digestive tract disorders rather unspecific in dogs and may have multiple various other causes, and not expected following topical application of product. Potential oral ingestion not reported. Although sign rather unspecific, lethargy may exceptionally occur in particular sensitive dogs or may be consequence of digestive tract disorders. Even though more expected after oral ingestion, Permethrin has potential to cause slight neurological disorders (e.g. ataxia) in particular susceptible animals. Dilated pupils not expected following appropriate product application. Known that none of active ingredients in product has potential to provoke seizures in dogs, neither alone nor in combination. Seizures reported by owner and no vet consulted. Thus possibly misinterpretation of sign. Death not expected in dog after product application, as inconsistent with pharmacotoxicological product profile. Low level of information (necropsy not available). Considering breed of dog, other etiologies more probable. No signs of allergy/anaphylactic reaction reported. Onset time of digestive disorders, lethargy, dilated pupils, and circling consistent, time to onset of seizure and death long. Considering all aspects, product connection deemed to be unlikely.