New incident report
Incident Report Number: 2013-2856
Registrant Reference Number: 130008800
Registrant Name (Full Legal Name no abbreviations): Wellmark International
Address: 100 Stone Road West, Suite 111
City: Guelph
Prov / State: Ontario
Country: Canada
Postal Code: N1G5L3
Domestic Animal
Country: UNITED STATES
Prov / State: OHIO
PMRA Registration No. PMRA Submission No. EPA Registration No. 2724-814
Product Name: Kirkland Signature Flea And Tick Control For Cats 5lbs + over
Liquid
Yes
Units: mL
Site: Animal / Usage sur un animal domestique
Medical Professional
Cat / Chat
Siamese
1
Female
6.5
5.18
lbs
Skin
>1 mo <= 6 mos / > 1 mois < = 6 mois
>1 mo <=2 mos / > 1 mois < = 2 mois
System
Persisted until death
Yes
Yes
Unknown
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On November 1, 2012 the owner noticed that the cat had lost weight. On January 21, 2013 the owner noticed that the cat had fleas and took the cat to her regular veterinarian. A chemistry profile was done and it was determined that the cat was dehydrated and the heart rate was recorded as 120.0 beats per minute (bpm); although that reading was normal, the veterinarian thought that perhaps the cat was actually bradycardic considering she was dehydrated and unwell. A short time later that morning, the owner's regular veterinarian contacted the Animal Product Safety Service (APSS) to obtain help. The APSS veterinarian stated that etofenprox is a non-ester pyrethroid and that its mechanism of action is similar to pyrethroids. The APSS veterinarian said that renal disease is not an expected clinical sign. The APSS veterinarian recommended that the regular veterinarian perform a diagnostic evaluation, provide symptomatic and supportive care, and call back with questions.
Death
On January 22, 2013 the owner's regular veterinarian called the APSS to update the case. The regular veterinarian stated that the owner mentions that a fogger product had been used in the home as well, and the APSS veterinarian stated that the fogger was an unlikely cause. According to the treating veterinarian the cat was anemic; the blood urea nitrogen, serum creatinine, and serum phosphorous were all high, and the cat was determined to have azotemia, hyperphosphatemia; and hypokalemia; finally, the cat's urine specific gravity was recorded as 1.011 and the cat was determined to have isothenuria and urine casts. The APSS veterinarian recommended that the regular veterinarian provide fluid diuresis. On January 24, 2013 the owner's regular veterinarian called the APSS to say that the cat had died at home on January 23, 2013. The owner took the cat back to the regular veterinarian, where the kidneys were removed for a histopath. The APSS technician recommended that a necropsy also be performed. On January 25, 2013 an APSS technician contacted the owner's regular veterinarian to discuss a necropsy, and the regular veterinarian confirmed they were going to send the body for necropsy. Final results of the necropsy were received on February 8, 2013; COMMENTS: This animal has a chronic-active pancreatitis. Symptomolo0gy form the pancreatitis is suspected. The clinical history (blood chemistry) is suggestive of renal disease; however, kidneys and adrenal gland were removed prior to necropsy examination and were not available for examination. On February 12, 2013 the DVM reported that the histo on the kidneys showed glomerulo-nephropathy caused by immune complex deposition. According to the Veterinarian at APSS weight loss, presumed renal dz, and dehydration are not related to product exposure.