New incident report
Incident Report Number: 2011-5861
Registrant Reference Number: 110120251
Registrant Name (Full Legal Name no abbreviations): Wellmark International
Address: 100 Stone Road West, Suite 111
City: Guelph
Prov / State: Ontario
Country: Canada
Postal Code: N1G5L3
Domestic Animal
Country: UNITED STATES
Prov / State: WISCONSIN
PMRA Registration No. PMRA Submission No. EPA Registration No. 2724-404
Product Name: Zodiac Fleatrol Flea And Tick Spray For Dogs Cats Puppies And Kittens
Liquid
Yes
Unknown
Site: Animal / Usage sur un animal domestique
Medical Professional
Cat / Chat
Domestic Shorthair
1
Female
8.0
4.5
kg
Skin
>15 min <=2 hrs / >15 min <=2 h
<=30 min / <=30 min
System
Persisted until death
No
No
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On the evening of September 17, 2011 the owner noticed the cat was having fasciculations. A short time later, early on September 18, 2011 the owner observed the cat died on the way to the veterinarian. Later on the morning of September 18, 2011 the owner's emergency veterinarian contacted the Animal Product Safety Service (APSS) to obtain help. The APSS veterinarian stated that pyrethrin sprays have a good margin of safety in cats and that significant central nervous system (CNS) signs were not expected. The APSS veterinarian recommended that the emergency veterinarian obtain the EPA registration number of the product, have a necropsy done if the owner approved it, and call back.
Death
The APSS veterinarian stated that the substance was considered to have a doubtful likelihood of causing the clinical situation. On September 18, 2011 the emergency veterinarian called the APSS to provide the EPA registration number. On September 19, 2011 an APSS technician contacted the emergency veterinarian to discuss a necropsy. On September 23, 2011 an APSS technician spoke with the emergency veterinarian and they confirmed the body had been sent for a necropsy. Later that day, an APSS technician spoke with the diagnostic laboratory staff to confirm the submission. On October 12, 2011 final necropsy information was received. Per necropsy results, the cat was infested with fleas, with extensive amounts of flea dirt on the skin; the cat was obese; the heart revealed moderate left ventricular concentric myocardial hypertrophy, the lung revealed mild diffuse pulmonary edema, the liver revealed subacute mild centrilobular hepatocyte degeneration and atrophy, the kidney revealed mild to moderate multifocal interstitial nephritis, the bone marrow revealed mild to moderate erythroid hyperplasia, the pancreas revealed moderate multifocal pancreatic islet amyloidosis, and the adrenal gland revealed focal cortical hyperplasia. The results indicated that the cause of death could be attributed to myocardial hypertrophy and insufficiency, resulting in the observed pulmonary edema. The results also indicated that there was evidence of centrilobular hepatocellular degeneration and atrophy that likely resulted from decreased right sided functions. The changes in the kidney are common in adult animals and their clinical significance was uncertain, but could reflect decreased renal function as well. The decreased cardiac output may have resulted in poor tissue perfusion and hypoxia, stimulating increased erythropoiesis in the bone marrow. The islet amyloidosis suggested the potential for diabetes mellitus. The adrenal hyperplasia was likely an incidental finding. The APSS veterinarian reassessed the case and stated that hypertrophic cardiomyopathy was considered to have a high likelihood of causing the clinical situation.