New incident report
Incident Report Number: 2011-5710
Registrant Reference Number: 110099813
Registrant Name (Full Legal Name no abbreviations): Wellmark International
Address: 100 Stone Road West, Suite 111
City: Guelph
Prov / State: Ontario
Country: Canada
Postal Code: N1G5L3
Domestic Animal
Country: UNITED STATES
Prov / State: WASHINGTON
PMRA Registration No. PMRA Submission No. EPA Registration No. 2724-504
Product Name: Zodiac Spot On Plus Flea And Tick Control For Cats 5 Pounds And Over
Liquid
Yes
Units: mL
Site: Animal / Usage sur un animal domestique
Animal's Owner
Cat / Chat
Domestic Shorthair
1
Male
10.0
12.0
lbs
Skin
>1 mo <= 6 mos / > 1 mois < = 6 mois
>30 min <=2 hrs / >30 min <=2 h
System
Persisted until death
Yes
Unknown
Died
Treatment / Traitement
(eg. description of the frequency and severity of the symptoms
On June 30, shortly after the product was applied to the cat, the owner noticed he was anorexic, adipsic, lethargic, hiding, vocalizing, and trembling. About an hour later, the cat was no longer vocalizing. On July 1, 2011 the cat had isolated events of hind limb weakness and hypersalivation, and the cat also became hyperesthetic.. By July 5, 2011, all of the signs except for the hyperesthesia had ended. On July 18, 2011 the owner noticed the cat was anorexic again. On July 30, 2011 the owner applied the product to the cat again, and the cat once again was adipsic, lethargic, hiding, vocalizing, and trembling. On August 2, 2011 the owner took the cat to the veterinarian, where he was given vitamin B, fluid therapy, and Enrofloxacin. On August 3, 2011 the owner contacted the Animal Product Safety Service (APSS) to obtain help. The APSS veterinarian stated that the product does not cause systemic effects, but that some cats may be sensitive to the carriers, or the active ingredients. The APSS veterinarian also stated that the signs often resolve within a few days and/or after bathing and that hypersalivation is common from the odor or from the taste of the product. The APSS veterinarian stated that renal damage would not be expected to be directly related to the product. The APSS assistant recommended that the owner bathe the cat with liquid dish washing detergent (LDWD) and rinse well, monitor the cat at home, apply a cold compress and vitamin E, give canned food, take the cat to the veterinarian, have the veterinarian call for information, and call back with questions.
Death
On August 6, 2011 the owner contacted the APSS to update the case. The owner stated that at an unknown date and time she bathed the cat, monitored him at home, applied a cold compress and vitamin E, and gave canned food. The owner stated that on August 5, 2011 she took the cat to the veterinarian, where a chemistry profile revealed that the cat had renal disease and was in kidney failure. The APSS veterinarian recommended that the owner obtain additional information about lab values and if a urine specific gravity was done, have a urine specific gravity done by the regular veterinarian, take the cat to the veterinarian for fluids if he had renal disease, and call back. Later that day, the owner called back to update the case. The owner stated that the cat was anemic, with hematocrit measured at 24.5 percent volume to volume (% v/v). The owner also stated that the cat had elevated blood urea nitrogen, which was measured at 185.0 milligrams per deciliter (mg/dL); had elevated creatinine, with serum creatinine recorded as 11.6 mg/dL; and had hyperphospatemia, with serum phosphorus recorded as 12.3 mg/dL. On August 15, 2011 the owner called to update the case. The owner stated that the cat had been receiving subcutaneous fluids at home and that he died on August 18, 2011. A necropsy was not available. The veterinarian at APSS suspected that the cat had chronic issues developing for some time.