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Incident Report
Subform I: General Information
1. Report Type.
New incident report
Incident Report Number: 2011-3085
2. Registrant Information.
Registrant Reference Number: 07192011 - MCPA
Registrant Name (Full Legal Name no abbreviations): MCPA Task Force Three (members: Nufarm bv, Dow AgroSciences, Albaugh Inc.)
Address: 44 Tamarack Circle
City: Toronto
Prov / State: Ontario
Country: CANADA
Postal Code: M9P 3T9
3. Select the appropriate subform(s) for the incident.
Scientific Study
4. Date registrant was first informed of the incident.
5. Location of incident.
6. Date incident was first observed.
Product Description
7. a) Provide the active ingredient and, if available, the registration number and product name (include all tank mixes). If the product is not registered provide a submission number.
Active(s)PMRA Registration No. PMRA Submission No. 2005-4106 EPA Registration No.
Product Name: MCPA Acid
- Active Ingredient(s)
- MCPA (PRESENT AS ACID)
7. b) Type of formulation.
Application Information
8. Product was applied?
Unknown
9. Application Rate.
10. Site pesticide was applied to (select all that apply).
11. Provide any additional information regarding application (how it was applied, amount applied, the size of the area treated etc).
To be determined by Registrant
12. In your opinion, was the product used according to the label instructions?
Unknown
Subform VII: Scientific Study
1. Study Reference
Title 6(a)(2) letter for BASF Study Titled "Subacute 28-day inhalation toxicity study in Wistar rats dust exposure"
Date 19-JUL-11
2. a) Is an extension needed to translate the document?
No
3. Type of incident identified in the study
New health or environmental hazard
4. Describe the incident identified in the study (e.g. study demonstrates an increased risk to non-Hodgkin's Lymphoma after exposure to pesticide X)
The MCPA Task Force Three is submitting interim results of a subacute 28-day dust aerosol inhalation study in Wistar rats with MCPA acid, conducted by BASF SE. Ten male and ten female Wistar rats per test group were exposed (nose-only) to dust aerosol of MCPA acid for 6 hours a day, 5 days a week for 4 weeks (total 20 exposures). The initially targeted concentrations were 50, 200 and 1000 mg/m3. A concurrent control group was exposed to clean air. After the first 3 exposures, the concentrations were reduced to 20, 100 and 500 mg/m3 following clinical signs of toxicity, indicative of an extreme irritant response. The revised concentrations were administered from exposure day 4 for males and exposure day 3 for females until scheduled termination. See 6(a)(2) letter submitted to US EPA on July 19, 2011 for details on the most relevant results.
5. a) Was the study discontinued before completion?
No
5. b) Provide the reason for discontinuation
6. If the study is ongoing, what is the expected completion date?
Unknown
