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Incident Report
Subform I: General Information
1. Report Type.
Update the report
Incident Report Number: 2010-6118
2. Registrant Information.
Registrant Reference Number: 112310-01 DTF
Registrant Name (Full Legal Name no abbreviations): Industry Task Force II on 2,4-D Research Data (members: Agro Gor Corporation, Dow AgroSciences LLC and Nufarm Americas, Inc.)
Address: 1900 K. St, NW
City: Washington
Prov / State: DC
Country: USA
Postal Code: 20006-1108
3. Select the appropriate subform(s) for the incident.
Scientific Study
4. Date registrant was first informed of the incident.
5. Location of incident.
6. Date incident was first observed.
Product Description
7. a) Provide the active ingredient and, if available, the registration number and product name (include all tank mixes). If the product is not registered provide a submission number.
Active(s)PMRA Registration No. PMRA Submission No. 2002-0726 EPA Registration No.
Product Name: 2,4-D 2-EHE
- Active Ingredient(s)
- 2,4-D (PRESENT AS LOW VOLATILE ESTERS)
7. b) Type of formulation.
Application Information
8. Product was applied?
Unknown
9. Application Rate.
10. Site pesticide was applied to (select all that apply).
11. Provide any additional information regarding application (how it was applied, amount applied, the size of the area treated etc).
To be determined by Registrant
12. In your opinion, was the product used according to the label instructions?
Unknown
Subform VII: Scientific Study
1. Study Reference
Title Acute Dietary Toxicity of 2,4-D 2-EHE in Mice
Date 23-NOV-10
2. a) Is an extension needed to translate the document?
No
3. Type of incident identified in the study
Presence of a component or derivitive
4. Describe the incident identified in the study (e.g. study demonstrates an increased risk to non-Hodgkin's Lymphoma after exposure to pesticide X)
The purpose of the study was to determine the dietary toxicity of 2,4-dichlorophenoxyacetic acid (2,4-D), administered as the 2-ethylhexyl ester (2-EHE) to small mammalian species. Specifically this Endocrine Disruption Screening Program (EDSP) assay/study is new information from a dietary lethal dose acute toxicity study (LDD50) with 2,4-D 2-EHE in mice. Because of extreme avoidance of the test diet, consumption values were reduced by over 90% compared to control animals. Based on food consumption and bodyweights, the LDD50 for 2,4-D 2-EHE is greater than 493 mg/kg. The Task Force is of the opinion that this study does not demonstrate that 2,4-D 2-EHE causes unreasonable adverse effects. Any adverse effects in this study were due to a lack of palatability and not toxicity of the dietary test material.
5. a) Was the study discontinued before completion?
No
5. b) Provide the reason for discontinuation
6. If the study is ongoing, what is the expected completion date?
15-DEC-10
