New incident report
Incident Report Number: 2008-2846
Registrant Reference Number: Prosar case 1-16243665
Registrant Name (Full Legal Name no abbreviations): Syngenta Crop Protection Canada, Inc.
Address: 140 Research Lane, Research Park
City: Guelph
Prov / State: Ontario
Country: Canada
Postal Code: N1G4Z3
Domestic Animal
Country: UNITED STATES
Prov / State: MICHIGAN
PMRA Registration No. 8661 PMRA Submission No. EPA Registration No.
Product Name: Gramoxone
Liquid
No
Unknown
Medical Professional
Dog / Chien
Blue Heeler
1
Female
6.5
45
lbs
Unknown
Unknown / Inconnu
Unknown / Inconnu
System
Persisted until death
Yes
Yes
1
Day(s) / Jour(s)
Died
Other / Autre
specify No witnessed exposure. Dog was locked in shed for 1.5 days; product was in the shed along with others. Presumed exposure.
(eg. description of the frequency and severity of the symptoms
1-16243665: The reporter, a (job title), called on 6/6/08 to report possible ingestion by a 6.5 year old dog of a product containing the active ingredient Paraquat. According to the reporter, the dog had accidentally been locked in a shed for 1.5 days. While there was no witnessed exposure, the product had been in the shed along with other products. The dog had presented to the veterinary clinic on 6/6 with lethargy, anorexia, vomiting, bloodwork abnormalities, labored breathing, and had been diagnosed with renal failure. BUN was elevated (68, 27 high normal), as was Creatinine (3.2, high normal 1.8), Phosphorus (11.1, high normal 6.8), and glucose (168, high normal 143). There were mild elevations in TP (8.9, high normal 8.2), Albumin (4.3, high normal 4), and Globulins (4.6, high normal 4.5). Liver enzymes were normal, but Amylase was elevated at 2006 (high 1500). Electrolytes were all low (Sodium at 142, low normal 144; Potassium at 2.3, low normal 3.5; and Chloride at 97, low normal 109). Mild elevations in HCT (56.8, high 55) and Hgb (20.1, high 18) were present. The Lymphocyte count was low (0.48, range 0.50-4.90) and the Monocyte count was elevated (2.24, range 0.3-2). At the time of the call, the dog had been bathed and placed on IV fluids. The safety profile of the product was discussed in terms of its potential for causing acute pulmonary edema and acute renal failure. A recommendation was made to obtain baseline chest x-rays and then recheck them periodically, as the edema could be delayed. It was also recommended to rehydrate the dog with IV fluids at 2-3 times maintenance rate, monitoring for the potential for oliguric renal failure. Anti-emetics and nutritional support were further recommended. The reporter was encouraged to consider that, since there was no witnessed exposure, other products in the shed or even other illnesses could be playing a part in the dog¿s symptoms was well. A follow-up call revealed the dog had passed away the evening of 6/7.
Death
The dog was locked in a shed for 1.5 days in summer. There is no evidence that this particular product was accessible to the dog.