Incident Report

Subform I: General Information

1. Report Type.

New incident report

Incident Report Number: 2007-8698

2. Registrant Information.

Registrant Name (Full Legal Name no abbreviations): Bayer Inc

Address: 77 Belfield Rd

City: Toronto

Prov / State: ON

Country: Canada

Postal Code: M9W 1G6

3. Select the appropriate subform(s) for the incident.

Domestic Animal

4. Date registrant was first informed of the incident.

01-AUG-07

5. Location of incident.

Country: UNITED STATES

Prov / State: UNKNOWN

6. Date incident was first observed.

05-JUN-07

Product Description

7. a) Provide the active ingredient and, if available, the registration number and product name (include all tank mixes). If the product is not registered provide a submission number.

Active(s)

---

PMRA Registration No.       PMRA Submission No.       EPA Registration No.

Product Name: advantage

• Active Ingredient(s)
  • IMIDACLOPRID
    • Guarantee/concentration 9.1 %

---

7. b) Type of formulation.

Liquid

Application Information

8. Product was applied?

Yes

9. Application Rate.

Unknown

10. Site pesticide was applied to (select all that apply).

Site: Animal / Usage sur un animal domestique

11. Provide any additional information regarding application (how it was applied, amount applied, the size of the area treated etc).

Clinic states that owner applied two tubes of Advantage on this cat 48 hours ago.

To be determined by Registrant

12. In your opinion, was the product used according to the label instructions?

No

Subform III: Domestic Animal Incident Report

1. Source of Report

Medical Professional

2. Type of animal affected

Cat / Chat

3. Breed

DSH

4. Number of animals affected

1

5. Sex

Male

6. Age (provide a range if necessary )

0.16

7. Weight (provide a range if necessary )

4.5

kg

8. Route(s) of exposure

Skin

9. What was the length of exposure?

>24 hrs <=3 days / >24 h <=3 jours

10. Time between exposure and onset of symptoms

>24 hrs <=3 days / >24 h <=3 jours

11. List all symptoms

System

• Nervous and Muscular Systems
  • Symptom - Convulsions
  • Symptom - Rigidity

• General
  • Symptom - Death

12. How long did the symptoms last?

Persisted until death

13. Was medical treatment provided? Provide details in question 17.

No

14. a) Was the animal hospitalized?

Yes

14. b) How long was the animal hospitalized?

Unknown

15. Outcome of the incident

Died

16. How was the animal exposed?

Treatment / Traitement

17. Provide any additional details about the incident

(eg. description of the frequency and severity of the symptoms

Clinic states that owner applied two tubes of Advantage on this cat 48 hours ago. Today the cat has presented with "convulsions, and rigid". The owner bathed this cat, but no other treatment has been administered. Sited the mode of action of Advantage. Explained that even at increased doses, it would not be expected to see these symptoms with this product. Suggested to have owner bring packaging into clinic to verify product. Explained the symptoms following the accidental application of K9 Advantix to a cat, but it would be unusual to see symptoms 48 hours after exposure. Explained to not limit the rule outs for this case to the advantage, as the symptoms may be related to other causes.

---

To be determined by Registrant

18. Severity classification (if there is more than 1 possible classification

Death

19. Provide supplemental information here

Contacted clinic for follow-up. Receptionist states that the cat died shortly after admission to the clinic. No necropsy was performed.