Update the report
Incident Report Number: 2007-7268
Registrant Reference Number: 2007Oct Canada DCSA 2Gen
Registrant Name (Full Legal Name no abbreviations): Monsanto
Address: 800 North Lindbergh Blvd.
City: Saint Louis
Prov / State: Missouri
Country: United States of America
Postal Code: 63167
Scientific Study
PMRA Registration No. 27200 PMRA Submission No. EPA Registration No.
Product Name: Rustler Herbicide
Unknown
Unknown
Title A Dietary Two-Generation Reproductive Toxicity Study of MON 52708 in Rats
Date 02-OCT-07
No
Increased health or environmental risk
In a 2-generation reproduction study, DCSA was administered daily to three groups of 30 male and 30 female rats at dietary concentrations of 0, 50, 500, and 5000 ppm for approximately 70 days. The animals were then mated; impregnated females were then allowed to carry their offspring to term, after which they delivered first generation pups. Parental toxicity was observed in the 5000 ppm F0 animals. Findings were statistically significantly decreased absolute body weights, body weight gains, and food consumption in both males and females. Statistically significantly decreased food consumption was also noted in 500 ppm F0 males. The F1 pups appeared to be comparable at birth relative to sex ratio, body weight, and general appearance based on external evaluations. By the fourth day of lactation, some of the 5000 ppm F1 pups were observed as having "ventral abdominal area blackened." Additional findings in these pups included bodies that were cool to touch and pale. Many of these pups died or were sacrificed in extremis. By the end of the 21-day lactation period surviving 5000 ppm F1 pups had absolute body weights that were >50% reduced compared to controls. Pups at 500 ppm had moderate but statistically significantly decreased body weights compared to controls at the post-natal day 14 and 21 time points.
No
31-AUG-08
Monsanto Company is currently evaluating the potential toxicity of 3,6-dichlorosalicylic acid (DCSA), which we believe to be an intermediate used in the manufacture of, and a known impurity in, as well as a plant and environmental metabolite of, the herbicide dicamba. Preliminary results from an incomplete study have come to our attention.