Update the report
Incident Report Number: 2007-5830
Registrant Reference Number: 2007July18 Dicamba
Registrant Name (Full Legal Name no abbreviations): Monsanto
Address: 800 North Lindbergh Blvd.
City: Saint Louis
Prov / State: Missouri
Country: United States of America
Postal Code: 63167
Scientific Study
PMRA Registration No. 27200 PMRA Submission No. EPA Registration No.
Product Name: Fortress Herbicide
Unknown
Unknown
Title Chromosomal Aberrations in Cultured Human Peripheral Blood Lymphocytes with MON 11900
Date 01-AUG-07
No
Increased health or environmental risk
Dicamba was negative in Ames, CHO/HGPRT, and micronucleus assays. It was also negative in an in vitro chromosomal aberration assay with human lymphocytes, with and without S-9, following a 3-hour treatment period in the initial assay. In the confirmatory assay, there was an increase in cells with chromosomal aberrations with S-9, but only at the highest level tested and in the presence of a precipitate and concomitant cytotoxicity. There was also an increase in cells with chromosomal aberrations following a 22-hour treatment period without S-9 at the highest levels tested and with concomitant cytotoxicity. Based on information reported in the Reregistration Eligibility Decision Document (RED) for dicamba, the chemical was negative in an in vitro chromosomal aberration assay with CHO cells. Furthermore, the RED also indicates that dicamba is not carcinogenic based on chronic studies performed with rats and mice. Based on the weight of evidence, the findings of the current study do not alter the conclusion that dicamba does not pose a genotoxic/carcinogenic risk to humans.
No
01-OCT-07
Monsanto Company is currently evaluating the potential toxicity of the herbicide dicamba. Preliminary results from incomplete studies have come to our attention.