Incident Report

Subform I: General Information

1. Report Type.

New incident report

Incident Report Number: 2017-0154

2. Registrant Information.

Registrant Reference Number: 160119266

Registrant Name (Full Legal Name no abbreviations): Wellmark International

Address: 100 Stone Road West, Suite 111

City: Guelph

Prov / State: Ontario

Country: Canada

Postal Code: N1G5L3

3. Select the appropriate subform(s) for the incident.

Domestic Animal

4. Date registrant was first informed of the incident.

12-AUG-16

5. Location of incident.

Country: CANADA

Prov / State: QUEBEC

6. Date incident was first observed.

11-AUG-16

Product Description

7. a) Provide the active ingredient and, if available, the registration number and product name (include all tank mixes). If the product is not registered provide a submission number.

Active(s)

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PMRA Registration No. 21573      PMRA Submission No.       EPA Registration No.

Product Name: Precor EC Emulsifiable Concentrate

• Active Ingredient(s)
  • (S)-METHOPRENE

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7. b) Type of formulation.

Application Information

8. Product was applied?

Yes

9. Application Rate.

Unknown

10. Site pesticide was applied to (select all that apply).

Site: Res. - In Home / Rés. - à l'int. maison

11. Provide any additional information regarding application (how it was applied, amount applied, the size of the area treated etc).

On August 10, 2016 the Pest Control Operator (PCO) sprayed the Zoecon product and two other products (Prelude and Air Guard) in the house. The cat was kept out of the house for 8 hours.

To be determined by Registrant

12. In your opinion, was the product used according to the label instructions?

Unknown

Subform III: Domestic Animal Incident Report

1. Source of Report

Medical Professional

2. Type of animal affected

Cat / Chat

3. Breed

Domestic Shorthair

4. Number of animals affected

1

5. Sex

Female

6. Age (provide a range if necessary )

2.0

7. Weight (provide a range if necessary )

8.0

lbs

8. Route(s) of exposure

Skin

9. What was the length of exposure?

Unknown / Inconnu

10. Time between exposure and onset of symptoms

>8 hrs <=24 hrs / > 8 h < = 24 h

11. List all symptoms

System

• Skin
  • Symptom - Hyperesthesia

• Gastrointestinal System
  • Symptom - Anorexia

• Eye
  • Symptom - Nystagmus

• Nervous and Muscular Systems
  • Symptom - Ataxia

12. How long did the symptoms last?

Unknown / Inconnu

13. Was medical treatment provided? Provide details in question 17.

Yes

14. a) Was the animal hospitalized?

Unknown

14. b) How long was the animal hospitalized?

15. Outcome of the incident

Unknown/Inconnu

16. How was the animal exposed?

Contact treat.area/Contact surf. traitée

17. Provide any additional details about the incident

(eg. description of the frequency and severity of the symptoms

On August 11, 2016 the cat developed symptoms. The owner then took the cat to an emergency veterinarian, where they washed the cat's feet (liquid dish washing detergent (LDWD)), gave fluid therapy, and gave maropitant. On August 12, 2016 the cat still hadn't improved so the emergency veterinarian gave the cat methocarbamol and fluid therapy. Later that day, the emergency veterinarian called the Animal Product Safety Service (APSS). The APSS veterinarian stated with the Zoecon product s-methoprene is an insect growth regulator (IGR). The APSS veterinarian also stated if ingested there could be hypersalivation and nausea. The APSS veterinarian stated with the Prelude product cats do not tolerate permethrin and there are some individual variations in sensitivity. The APSS veterinarian stated signs range from mild parethesia, ataxia, and tremors to seizures and signs can develop from almost immediately up to 72 hours post exposure. The APSS veterinarian stated with the Air Guard piperonyl butoxide and n-octyl bicycloheptene dicarboximide (MGK-264) are synergists to enhance the efficacy of the ingredients and with ingestion expect oral paresthesia. The APSS veterinarian also stated common clinical signs may include gagging, retching, lip licking, increased swallowing, and vomiting from the tingling/burning sensation in the mouth and throat. The APSS veterinarian further stated these signs occur right after exposure and are usually self-limiting. The APSS veterinarian finally stated central nervous (CNS) signs are not expected. The APSS veterinarian recommended monitoring the cat at the veterinary facility for CNS and gastronintestinal (GI) signs, managing vomiting, fluid therapy, complete blood count, chemistry profile, radiographs (examine bullae), and calling back with questions. The APSS veterinarian discussed the case with the attending emergency veterinarian and stated that some of the signs could fit with a paresthesia reaction to the pyrethroids and pyrethrins, but would not expect the nystagmus. The APSS veterinarian recommended if the cat is not improving overnight, would want to look into other causes.

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To be determined by Registrant

18. Severity classification (if there is more than 1 possible classification

Moderate

19. Provide supplemental information here

The APSS veterinarian stated that the Zoecon was considered to have a doubtful likelihood of causing the clinical situation. The APSS veterinarian stated that the Prelude was considered to have a low likelihood of causing the clinical situation. The APSS veterinarian stated that the Air Guard was considered to have a low likelihood of causing the clinical situation.